Power Foods For the Brain – a TED talk

A TEDx talk by Dr. Neil Barnard, Power Foods for the Brain, gives a helpful overview of healthy eating and exercise for protecting against memory decline as we age. Even with the gene that has been linked to higher risk for age related memory loss eating a diet with less saturated and trans fats was helpful.

Colorful phytonutrients and benefits of antioxidants is also discussed. Anthocyanins, the purple color in blueberries and grapes, are antioxidants that help protect the produce from excess sunshine and can help our bodies from the negative effects of stress whether from metabolic oxidative stress or daily stress. Anthocyanins are discussed around 11:00.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

 

Ellagitannins and red raspberries

Prior to the research on pomegranates and ellagitannins research was being performed on the use of red raspberries for their health and anticancer benefits. The summary points are that the whole fruit, the mixture of a variety of phytonutrients provides the benefits and that an isolated singe phytonutrient may be less bioavailable and less bioactive – less chemically likely to provide benefits as the mixture of phytonutrients that the whole food provides. An article from 2001 discusses this in more detail and mentions that early work on pomegranates suggested they would be an even better source of the group of ellagitannins and other polyphenols.

The compounds when working together within the body seem to help make cancer cells stop dividing and start dying by apoptosis like normal cells would – and without having any toxic effects on other normal healthy cells. The ellagitannins and other phytonutrients in red raspberries also seemed to prevent precancerous cells from becoming cancerous – dividing at above average rate of growth.

Other health benefits of the whole fruit used as a fruit puree equivalent to eating one cup of red raspberries per day, providing 40 mg of ellagitannins, included:

“European medical studies also demonstrate that red raspberry ellagitannins lower the incidence of birth defects, promote wound healing, reduce heart disease, and may reduce or reverse chemically induced liver fibrosis. In addition, the ellagic acid produced from the ellagitannins has anti-bacterial and anti-viral properties.”

Read more: The Truth About Ellagic Acid and Red Raspberries,    https://jonbarron.org/article/truth-about-ellagic-acid-and-red-raspberries

Ellagitannins and pomegranates was a discussion begun in a previous post: Pomegranate polyphenols and Microglia M2 Activation. I didn’t include the information in my summary but one of the links mentions that whole pomegranate juice / juice made with the peel / provides about 2 grams per liter of ellagitannins which would be many times more than 40 milligrams. Two grams would be 2000 milligrams and a liter is slightly less than a quart which is four cups, so roughly the whole pomegranate juice/extract is providing 500 milligrams per cup. A cup of juice would be more concentrated, being a liquid, compared to a cup of loosely packed whole red raspberries with seeds and air space, so a cup of raspberry puree or red raspberry juice would likely provide more than 40 milligrams.

Black raspberries are a dark purple color were not mentioned in the 2001 article but a more recent study on cancer therapy from 2016 mentions them as a source of ellagic acid so they may have an equivalent amount of the beneficial phytonutrients.

Read more: Black raspberries in cancer clinical trials: Past, present and future.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008867/

Blueberries and blackberries and other berries are good sources of a variety of beneficial phytonutrients. Many types have the most prevalent phytonutrients listed and extraction methods that are typically used for commercial products are discussed in this research review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384171/

A shorter article discussing phytonutrients found in blueberries, blackberries and raspberries in a more general way:   http://berryhealth.fst.oregonstate.edu/symposium/lukehowardabstract.htm

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Pomegranate polyphenols and Microglia M2 activation

The short story is that pomegranate polyphenols activate a very strong positive defense mechanism against inflammation that may be less active in autism. Read more:

Pomegranate juice polyphenols induce a phenotypic switch in macrophage polarization favoring a M2 anti-inflammatory state. (1)

“Pomegranate juice given daily for 2 years to 40 prostate cancer patients with increasing PSA levels provides evidence for the possible utilization of a nontoxic option for prevention or delay of prostate carcinogenesis. It is remarkable that 85% of patients responded to pomegranate juice in this study.” Pomegranate Ellagitannins – Herbal Medicine, (4)

(Punicagilanin and other polyphenols from a group called ellagitannins are found in the pomegranate juice and more are available when the entire fruit is used to extract juice. The bioactive phytonutrients seem to start being excreted from the body within 12 hours based on clinical studies, so a daily intake would be required for consistent benefits. Pomegranate Ellagitannins – Herbal Medicine, (4))

The long story is best left to read on a website written by a doctor who is working with research on the role of endocannabinoids in autism, how they may be involved in the risk as well as treatment for patients with the condition.

  • Read more: What Glyphosate Does To Your Brain: (2), which is a continuation of an overview on the topic of the herbicide glyphosate, autism and an endogenous cannabinoid that acts on the CB2 receptors.
  • Read more: The Autism Brain, Glyphosate, and Super-Cannabinoid Production (3)
  • Glyphosate was originally produced as an antibiotic and mineral chelator and may affect many pathways in the body due to changes to enzyme and mineral access and due to its chemical similarity to an important amino acid, glycine, which can act as a brain neurotransmitter.

So the short story is our body needs endogenous cannabinoids to protect our brain and the brains of infants from inflammatory toxins and pomegranate polyphenols may be a substitute as well as the non-euphoric cannabinoid CBD which activates the CB2 receptors.

Other foods that also may provide some natural cannabinoids or polyphenols that affect the system beneficially may include the herb Rosemary, the spice Cardamom, and unrefined cocoa bean products such as dark chocolate and Baker’s Cocoa Powder or Baking Chocolate.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

  1. Saar Aharoni, Yoni Lati, Michael Aviram, Bianca Furhman,  Pomegranate juice polyphenols induce a phenotypic switch in macrophage polarization favoring a M2 anti-inflammatory state. Biofactors, Volume 41, Issue 1, Jan/Feb 2015
    Pages 44–51  http://onlinelibrary.wiley.com/doi/10.1002/biof.1199/full (1)
  2. Christian Bogner, MD, What Glyphosate Does to Your Brain, Jan. 16, 2017, http://drbogner.com/glyphosate-vs-brain/ (2)
  3. Christian Bogner, MD, The Autism Brain, Glyphosate, and Super-Cannabinoid Production, Dec. 10, 2016, http://drbogner.com/glyphosate-autism-2/ (3)
  4. David Heber, Chapter 10: Pomegranate Ellagitannins,Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition., Benzie IFF, Wachtel-Galor S, editors. Boca Raton (FL): CRC Press/Taylor & Francis; 2011., https://www.ncbi.nlm.nih.gov/books/NBK92772/ (4)

Cancer treatment for zero dollars?

I realize pomegranate peel as a health commodity is a tough sell at the difficult price point of zero dollars but some people can’t afford a quarter million dollars. (The zero dollars is simply referencing the fact that pomegranate peel is thrown out currently and the fruit is purchased for the seeds or used to create juice – so not throwing out the peel would be a zero dollar amount but time to create an extract and to store it in a freezer or dehydrate it into capsules would involve some cost in time and supplies – but we have to start somewhere and the starting point here is recognizing that throwing out the peel is wasting valuable health protective phyto-nutrients.)

Research has to start somewhere. Animal research may be followed by human cell cultures and eventually make it to clinical trials with human patients.  Call me patient zero as I have found it helpful for anxiety and numbness in my fingertips (possibly an early sign of Raynaud’s Disease but I don’t have a diagnosis of that condition – actually I’m not patient zero: https://www.healthboards.com/boards/raynauds-syndrome/963422-raynaud-problem.html,and pomegranate extract can be purchased for more than zero dollars in capsule, microgram doses: https://www.google.com/search?q=pomegranate+extract+250+mg&rlz=1C1CHWA_enUS600US600&oq=pomegranate+extract+250+mg&aqs=chrome..69i57&sourceid=chrome&ie=UTF-8 )(I use more than a 250 mg amount of my homemade extract, a few tablespoons throughout the day in a few different foods would equal about 60-90 grams/4-6 Tablespoons).

Pomegranate extract has been found beneficial in animal research for hypertension  (5) and for cancer, (6).

“PE (Pomegranate Extract) treatment (1 or 10 g/kg), started 4 weeks prior to the DENA challenge and continued for 18 weeks thereafter, showed striking chemopreventive activity demonstrated by reduced incidence, number, multiplicity, size and volume of hepatic nodules, precursors of HCC (Hepatocellular Carcinoma).” (6)

In a more recent post a reference to a book chapter reveals that a human trial for prostate cancer was found beneficial for 85% of the patients. It was a small study with only 40 patients but that is an astonishing success rate for the average cancer treatment, I’ve seen some chemotherapy treatments listed with warnings to not be used for frail older patients as the survival rate was 10% – flip that around and it is a successful poison rate of 90%.

The prostate cancer reference:

“Pomegranate juice given daily for 2 years to 40 prostate cancer patients with increasing PSA levels provides evidence for the possible utilization of a nontoxic option for prevention or delay of prostate carcinogenesis. It is remarkable that 85% of patients responded to pomegranate juice in this study.” Pomegranate Ellagitannins – Herbal Medicine, (4)

(Punicagilanin and other polyphenols from a group called ellagitannins are found in the pomegranate juice and more are available when the entire fruit is used to extract juice. The bioactive phytonutrients seem to start being excreted from the body within 12 hours based on clinical studies, so a daily intake would be required for consistent benefits. Pomegranate Ellagitannins – Herbal Medicine, (4))

Using pomegranate peel or whole fruit extract is not only likely to have fewer negative side effects such as hair loss or severe vomiting but the cost savings isn’t a joke. Even if health insurance covered most of a $250,000 chemotherapy treatment the copays would still add up. Ten percent copays would be $25,000 and 20% would be $50,000. Many people can’t afford that, let alone an uninsured person trying to pay the $250,000. The other side effect that isn’t discussed much is a long term or lingering loss in cognitive skills following chemotherapy. Patients may not be able to return to their former jobs after recovery from cancer with standard chemotherapy treatments. Here’s an article about the sticker shock that can occur with hidden costs for having a baby in our modern hospitals – the specialist doctors may not be considered inhouse and covered by insurance in the same way as the doctor for average deliveries. Families go bankrupt over the copays left from having a baby in the U.S.. That is unusual compared to other developed nations. https://www.theguardian.com/us-news/2018/jan/16/why-does-it-cost-32093-just-to-give-birth-in-america

Not developing the cancer in the first place by helping your body to have a strong and healthy defense system is ideal and the Nrf2 promoting foods, which have been discussed in the latest series of posts and which included pomegranate, may all help with daily protection of the body against inflammatory conditions and with detoxification of toxins which may underly increased risk for cancer.

Pomegranate extract and its potential  for health benefits and other Nrf2 promoting foods was discussed in an earlier post: http://transcendingsquare.com/2017/12/24/it-is-not-a-coincidence-that-my-phospholipid-rich-diet-overlaps-with-nrf2-promoting-foods/

Pomegranate extract for the home cook (me) for individual research purposes regarding health and edible characteristics is described in this post: http://transcendingsquare.com/2017/12/31/master-chef-challenge-pomegranate-peel/ The second large batch I made I simmered for 20 minutes instead of 30 minutes as the shorter heating time retained a brighter color and many phytonutrients and antioxidants are colorful. The broth is quite acidic and I’ve primarily been using it in recipes in place of lime/lemon juice or salad vinegar.

Soup is good food and vegetable stock is made with washed produce peels and other sections of some types of produce. Not all produce makes good soup stock but the budget conscious cook tries things and finds out what works, or how to make it work.

Economic history, a collection of free ebooks that include a section on Austrian economics and Carl Menger, see The Essential Henry Hazlitt, 3. Understanding “Austrian” Economicshttps://fee.org/articles/these-five-freedom-philosophers-will-liberate-your-mind/

Capitalism versus socialism doesn’t have to be the only way to look at economic theory – longterm stewardship of the planet and its resources is discussed in the Austrian economics viewpoint and in this more modern and alternative view of our being part of the cosmos as energy beings:

For an alternative viewpoint on the economic value of viewing our time here as stewardship of the planet and its resources: – 10 Characteristics of Highly Evolved Beingshttps://wakeup-world.com/2018/01/10/10-characteristics-of-highly-evolved-beings/

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

  • Wenyan Sun, Chunhong Yan, Bess Frost, Xin Wang, Chen Hou, Mengqi Zeng, Hongli Gao, Yuming Kang,and Jiankang Liu,

    Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats., Sci Rep. 2016; 6: 34246.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054377/ (5)

  • Anupam Bishayee, Deepak Bhatia, Roslin J. Thoppil, Altaf S. Darvesh, Eviatar Nevo, and Ephraim P. Lansky.,  Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms., Carcinogenesis. 2011 Jun; 32(6): 888–896. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314278/ (6)