G3.6: Antihistamines may help if there is a genetic tendency to overproduce histamine.

Genetic differences in more than 70 genes have been associated with increased itchiness, see summary at the end of this section. (G3.24) Calcium and serotonin levels may be involved in increased itch or arthritis pain signals being sent or perceived. (G3.25) Scratching an itch is considered rude and a chronic itch is often considered funny however it isn’t fun.

Some background information:

Too much or too little calcium and magnesium can affect pain, itching, and mood. The minerals are both electrically active, and provide energy for ion channels which control the transport of messenger chemicals like serotonin across cell membranes – such as nerve cell membranes which might feel like a sensation of itchiness or pain.     

Excess serotonin may be involved, (G3.26, G3.27), and scratching an itch can make the urge to scratch more intense, even worse afterwards, even though there may be a temporary feeling of relief while scratching. (G3.28) Adequate magnesium is essential for reducing pain in arthritis or at least may help reduce pain levels. (G3.27) An antihistamine may help for some types of itching related to genetic conditions. (G3.29)

Excess dopamine levels can also be a cause of an overwhelming urge to scratch – see “grooming behavior” in section 7. When to Report?. The solution there is to figure out why dopamine levels are that elevated. Elevated dopamine can be a symptom of hyperthyroidism but it can also be associated with other conditions.

  • An Itch You Just Can’t Scratch; NIH-funded study identifies proteins that may cause chronic itch. Summary points: The HTR7 gene was found most closely associated with chronic itch in an animal based study, however over 70 genes were found to be more expressed, more active in lab animals with chronic itch. The gene expression of the HTR7 gene was most active in the mice with the worst symptoms of scratching compared to the mice with the least sensitivity. The activity of the TRP1 receptor was also increased in animals with more symptoms. (G.24)
  • Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice. Summary points: The TRPA1 receptor is directly activated by calcium levels inside of the cell, and a variety of toxins or “noxious” (irritating) substances that are produced as a normal part of “oxidative stress” otherwise known as “inflammation” including, “4-hydroxy-2-nonenal, hydrogen peroxide, hypochloride, hydrogen sulphide, 15-delta prostaglandin J2 [2528].” and irritants from the environment or diet can also activate the TRPA1 receptor, *1.mustard oil (allyl isothiocyanate: AITC) [29], *2. cinnamaldehyde [30, 31], *3. allicin [32, 33] and *4. formalin [34]…”. (G3.25) Serotonin and other “Inflammatory mediators, such as bradykinin…[19, 35]” (G3.25) can make the receptors more sensitive which can lead to increased responsiveness of nerve endings – more pain (G3.25) or itch. (G3.24) *See the next section for more information about the chemicals in bold font and where they may be found in the diet or environment.

*People with overactive TRPA1 channels may be sensitive to:

  1. Mustard:  “mustard oil”
  2. Cinnamon:  “cinnamaldehyde'” (G3.43) );
  3. Onion or Garlic:allicin,” (G3.41)
  4. Formaldehyde:formalin,” chemically the two are very similar: (G3.42) and formaldehyde is found in the environmental and as a metabolite of some alternative sweeteners and other dietary sources. (G3.56) Environmental sources include which would include first and second hand smoke, poorly ventilated air or smog, especially when there is brand new flooring or other new plastic or vinyl  material in the living area, it  can release volatile chemicals including formaldehyde at levels that can make a sensitive person feel ill. Metabolites of the breakdown of the alternative sweetener aspartame and Neotame include menthol and formaldehyde. (G3.44) Older packages of fruit juice also may contain increasing amounts of formaldehyde as the product ages, more of the chemical is produced from other chemicals.

Magnesium, Opioids, and Neuropathic Pain.

This list and this section got much longer actually, and eventually led me back to a topic I’ve written about in 2011, and which is one of the underlying causes of overactive TRP channels. Fortunately it also has a simple solution, (G3.101), but – unfortunately – it is so simple a solution that it isn’t profitable – unfortunately for individual patient’s health and quality of life and unfortunately for the economic health of individuals and nations and businesses who are being overcharged by the medical industry for healthcare that isn’t always effective and sometimes causes harm.

It is so effective a solution for improving mood and pain and muscle cramp type symptoms that I’ve been sharing the information online since at least 2011 and the article I shared was research from 2009, (G3.101), – so the clock is ticking on how soon the evidence based medical research will reach the individual patient who is in pain. The racers at the starting line are the physicians and nurse practitioners and other health professionals who make recommendations for opioid medications in an attempt to block pain instead of trying to find and resolve the cause of the pain.

What is a nerve signal? “Pain” or “no pain”? or “on” and “off”?
Pain, however, should not just be blocked without trying to understand the cause. It is a message from the body desperately asking for help but it is not always a clear message. Pain in one area of the body may have to do with an issue in another area of the body. Instead of blocking the pain signals we need to listen to them more carefully and try to figure out what the pain signals mean and how to resolve the underlying cause of the pain. Something might be missing and need to be added back into the diet or something might be happening in excess either in the diet or lifestyle habits and need to be stopped or moderated.

Nerve signals are not specific to send the brain a message of “pain” that exclusively means “pain;” a nerve signal is more of an “on” or “off” and might indicate a variety of extremes: too hot or too cold, or too rough or too light (ticklish), or too hot peppery, (capsaicin, (G3.100), more on that later), or too mustard oily. The nerve signal is simply telling the brain that “something” happened – figure it out captain of the ship – and fix it – such as remembering to wear gardening gloves before handling wild mustard weeds, especially if you have diabetic hypersensitivity.

The TRP channels are the bridge between the world and the nerve signal. There are many types and they can respond to specific temperatures, so some might activate when it is very cold and some might activate when it is very hot. Some might react to the hot pepper and some might react to the mustard oil. They would all tell the same nerve – “something” extreme happened.

Mustard oil can cause an extremely itchy reaction. It is used to induce “hypersensitivity” in lab animals to study the condition in relation to diabetic hypersensitivity. This will be discussed in the next section in more detail. (G3.96) Wearing gloves may be advisable when pulling a patch of wild mustard if you tend to have sensitive skin or allergic reactions.  (p124, G3.97)

Antihistamines taken daily can be helpful if excess histidine is a problem.

Antihistamines taken as a daily precaution may be helpful for people with overly sensitive skin if the sensitivity is related to a tendency to overproduce histidine. (G3.29) If that is an issue, then taking an antihistamine medication daily may also help for some types of chronic pain as well, more will be included in the next section. Acupuncture is a traditional therapy that may help reduce the overactivity of TRPV channels and reduce the production of the inflammatory peptide Substance P and other cytokines. Acupuncture can affect both the opioid and the cannabinoid receptors – but without needing the prescription or having to experience the side effects! (G3.104)

See a healthcare provider for medical advice, diagnosis or treatment.

  • Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

The Academy of Nutrition and Dietetics has a service for locating a nutrition counselor near you at the website eatright.org: (eatright.org/find-an-expert)

References:

Formaldehyde: Health risks, and Environmental and Dietary sources.

I mentioned in my last post, (a long time ago – I’ve been busy spring cleaning), that I would discuss oxidative stress next – some background information first:

(“Formaldehyde is a cause of oxidative stress.” LMGTFY: 1,450,000 results.)

Formaldehyde:  formaldehyde is a chemical that can be produced within the body as part of metabolism, it is toxic however and the body would continue to break it down further for removal from the body in conditions of normal health. Formaldehyde is found in the environment from a variety of sources and is produced in the body or in food products as a metabolite (a chemical produced from the digestion/metabolism of a larger chemical) of some alternative sweeteners (G.48) and other dietary sources including fruit juices and artificial and natural flavorings. ((G.49, (p476, G.50)) (G.56)  “Formalin” is chemically very similar and may cause similar health symptoms. (G.42(G.25Formalin is used to induce pain in lab animals for experimental purposes and it was determined that the pain was due to activation of the TRPA1 channels. (G.86)

Environmental and dietary sources of formaldehyde include, (G.56):

  1. First and second hand smoke, (G.44); The formaldehyde content of some types of E-Cigarette preparations used for “vaping” instead of smoking the volatile gases have been found to vary significantly. Skipping to the last point on this list may provide the explanation – fruit flavoring based on fruit juice and essential oils from fruit and other artificial “flavorings” are frequently chemicals from a group of chemicals called aldehydes. They can break down over time into smaller chemicals which can include formaldehyde or other toxic types of aldehydes. (G.49) So if you are “vaping” in order to avoid toxins in cigarette smoke then it may be advisable to skip the “chocolate or fruit flavoring” and use an E-Cigarette product that just has the natural tobacco flavor instead. (Yes, tobacco is an herb and it has a flavor and nicotine can have some health benefits, however formaldehyde does not. The nicotine patch provides a steady dose of nicotine without any volatile toxins.)
  2. Poorly ventilated air or smog; (G.45)
  3. Vinyl and PVC plastic products off-gas formaldehyde and other volatile chemicals at levels that can make a sensitive person feel ill. (G.45). A poorly ventilated room would increase the risk of the gases accumulating to more toxic levels. The wax refinishing treatments used to clean and shine vinyl flooring are also sources of formaldehyde and other toxic gases. One re-waxing session can produce as much volatile chemicals from the chemical products that are used to strip off the old layer of wax polish and add a new layer, as the vinyl floor itself would off-gas throughout all the years of its installation. So making a choice about which type of flooring to install is also making a choice about the  type of cleaning products that will be needed to maintain the floor. (G.46) A Cleaning Product Fact Sheet is available from the California Environmental Protection Agency Air Resources Board: (G.47). Types of flooring and other building materials are discussed in extensive detail in a review article regarding sources of Formaldehyde in the Indoor Environment: (G.45).
  4. Metabolites of the breakdown of the alternative sweetener aspartame and Neotame include menthol and formaldehyde. (G.48)  
  5. Older packages of fruit juice also may contain formaldehyde in amounts that can continue to increase as the product ages. The formaldehyde is produced as other chemicals become unstable over time and metabolically breakdown into a variety of smaller chemicals which include formaldehyde. The food preservative method of ionizing radiation has been found to increase the chemical breakdown of larger aldehydes in apple juice into formaldehyde and other chemicals with toxic properties. (p476, G.50)
  6. Before leaving the topic of formaldehyde, the symptoms of toxicity with workplace exposure to formaldehyde have been reported to include allergic type symptoms including: “sneezing/airways-related symptoms, itching and watery eyes.” (G.51) Formaldehyde exposure may also be a cause of systemic allergic contact dermatitis, (G.52, G.53, G.54), possibly even with symptoms of rash occurring on the eyelids.(G.55) A diet designed to avoid formaldehyde intake may be helpful for alleviating the eczema like rash. (G.52)

A summary, in reverse order;

Formaldehyde might be accumulating from several sources, (G.56):

  • Workplace exposure; Workers more at risk might include health professionals, (G.51); and hair stylists or nail salon technicians, (G.58); and funeral directors may be more at risk for developing the paralyzing chronic disease ALS, (G.59); some industries such as the garment and textile industry may have formaldehyde exposure, (G.63);
  • Aseptically packaged juices, the amount may collect in older packages as the product ages, ionizing radiation methods of food preservation have been found to increase the amount of toxic aldehydes including formaldehyde and therefore is not a recommended technique for the juice industry, (p476, G.50);
  • Nutrasweet (aspartame) and Neotame, alternative sweeteners. (G..48)
  • Vinyl flooring, cleaning products, and other PVC type of plastic products. (G.45, G.46, G.47);
  • Poorly ventilated air or smog. (G.45); *Note, lighting large numbers of decorative candles may be increasing volatile chemicals in your air supply. Also air fresheners and cleaning products may contain chemicals that break down into formaldehyde. (G.60) Lifestyle choices besides smoking cigarettes can negatively affect health. Try a fern for air freshening instead; give it a nickname and you might get some emotional benefits in addition to other physical health benefits. Plants can be useful household decorations because some types can clean the air of formaldehyde and other toxins. The original research was by a NASA scientist for use in keeping the air fresh in living environments for astronauts. For the most effective air cleaning ability, the plant does need to be watered and misted as its particular type requires, because the chemical removal of formaldehyde from the air is dependent on the roots and leaves access to water. (G.61); a mechanical problem with the furnace or water heater and ventilation system may be leaking toxic chemicals into the building’s air supply; increased efficiency of insulation and other building materials have created rooms and buildings that are too good at preventing air circulation, which makes maintenance and cleaning of ventilation systems and fans important – otherwise everyone working or living in the space might start feeling some symptoms of “sick building syndrome.” (G.62)
  • Smoking cigarettes or other products, and flavorings in “vaped” E-Cigarettes may also be a source of formaldehyde. (G.44, G.49)

Fact Sheets regarding Formaldehyde, Environmental Safety and Health:

  • The Centers for Disease Control provides a fact sheet for further guidance regarding risks and precautions regarding formaldehyde: What You Should Know About Formaldehyde, (G.57)
  • The Environmental Protection Agency provides a fact sheet on sick building syndrome: Fact Sheet: Sick Building Syndrome, (G.62)
  • The Cleaning Products Fact Sheet, by the California Environmental Protection Agency’s Air Resources Board provides guidance regarding safer cleaning products: (G.47)
  • The National Cancer Institute’s Fact Sheet: Formaldehyde and Cancer Risk includes research on occupations that may be at risk for formaldehyde exposure and provides a list of organizations that might have more information or other help to offer. (G.63)

Sick Building Syndrome: Symptoms that may occur due to breathing air that contains too much formaldehyde may include sore throat, cough, scratchy eyes, and nosebleeds according to the fact sheet by the Centers for Disease Control. (G.57) So if everyone working in a building, or many workers or family members are all experiencing allergies or a slight cold that just doesn’t seem to want to go away – then bad air may be a problem. See the fact sheet on Sick Building Syndrome by the EPA for more information. (G.62)

Eczema: The eczema symptoms reported in medical research may occur with more chronic long-term exposure to formaldehyde and/or in individuals who also have more difficulties metabolically with detoxifiying formaldehyde – we don’t know all the answers. I have personally experienced skin rashes off and on all my life and was startled to develop it on my eyelids in my more recent past – and then was more startled, or more relieved to learn of the possible cause – formaldehyde exposure (G.55) and systemic allergic contact dermatitis, (G.52, G.53, G.54) Poor air quality was a problem at the time in part due to water heater mechanical problems, and also first and secondhand smoke were contaminants in my air supply – I cleaned up and changed habits somewhat and my eyelid rash got better – yeah science! To me that seems like an example of effective self care and effective use of evidence-based medical research even if I had to read it on my own.

Other health risks include cancer and neurological conditions: The link between cancer and formaldehyde may be less strong than for neurological disorders such as ALS in funeral home directors, (G.59), or autism in a child whose mother had prenatal exposure to formaldehyde, (G.56), however research has found some cancers associated with occupational exposure to formaldehyde. The National Cancer Institute also has a fact sheet on the topic of formaldehyde and it includes a convenient list of addresses and websites for organizations that might have more information for workers concerned about exposure risks such as OSHA, the Occupational Safety and Health Administration,. (G.64) See the National Cancer Institute’s Fact Sheet: Formaldehyde and Cancer Risk for more information and resources regarding formaldehyde and occupational safety: (G.63)

Houseplants can help offices as well as astronauts:

If you are looking for a hair salon that is likely to have less formaldehyde and other volatile toxins in the air then look for one with lots of healthy ferns and other tropical low light houseplants. (G.61) If you are a hair salon or other business owner interested in improving the air quality in your establishment with the help of ferns and other houseplants, then hire a staff member who knows and loves plants because they do require some consistent care that can vary quite a bit depending on the type of plant – or buy the book by the NASA research scientist and have an employee learn how to care for your indoor air-cleaning garden.

The scientist, B. C. Wolverton, organized what he learned to help astronauts in an easy to use plant guide that lists the species of plants which were found most effective at cleaning air. The book, How to Grow Fresh Air: 50 Houseplants that Purify Your Home or Office, includes guidance for caring for each species and also lists them by the types of volatile chemicals that they were able to remove from the air. (G.66)

Large urban areas may have office plant services available where a greenhouse or florist shop supplies and maintains lovely office plants for a subscription or rental type of payment. An employee of the plant business has a route of subscribing businesses to visit each week in order to water, mist, and trim plants of any dead leaves, even a healthy plant will look sad if it is covered in a layer of dust and has a few dead leaves. Plants that are sick are simply returned to the greenhouse for care or recycling and the empty spot is filled with a replacement by the plant business employee.

Ambius is an example of an office-plant company with service locations available in many urban areas in both Canada and the United States. See the Ambius website for more information and service locations: Ambius.com.

Disclaimer

References:

Environmental toxins and neurodevelopmental disorders in children

A consensus statement has been released by the Project TENDR group regarding environmental toxins and the risk of neurodevelopmental disorders in children which include ADHD, autism, and learning and other neurodevelopmental disabilities.  Read more: http://scienmag.com/scientists-physicians-and-advocates-agree-environmental-toxins-hurt-brain-development/

An excerpt lists the environmental toxins the group has identified as potentially  increasing children’s risk of developing ADHD, autism or other neurodevelopmental or learning disorders (the bold font was added by me):

The chemicals and pollutants highlighted in the consensus statement as contributing to children’s learning, intellectual and behavioral impairments are:

* Organophosphate (OP) pesticides

* Polybrominated diphenyl ethers (PBDEs) used as flame retardants

* Combustion-related air pollutants, which include polycyclic aromatic hydrocarbons (PAHs), nitrogen dioxide and particulate matter

* Lead, with primary sources of water pipes and paint

* Mercury

* Polychlorinated biphenyls (PCBs), industrial chemicals that were commonly used in electrical equipment and now pollute landfills and water

More information on each of these compounds and how families can protect themselves from them is on the Project TENDR website: http://projecttendr.com.

A comparison to  a checklist on one of my older post’s for toxins to avoid in the hopes of preventing autism included four of the groups: 2. PBDEs, 6. PCBs, 4. lead and 5. (methyl) mercury. And 3. formaldehyde is also a combustion-related air pollutant but I will need to add the other combustion-related air pollutants and 1. Organophophate pesticides.

Other risks for neurodevelopmental disorders developing in children may include:

A list of toxins to avoid can be useful for generating a list of foods and lifestyle choices that may be more beneficial or more of a risk for an expectant infant.  Note the phrases “May be,” “might help,” or “might harm” are suggestions rather than firm claims; there are no guarantees in life. Evidence based medicine likes to suggest that there is enough evidence to support a recommendation as being conclusive but the evidence typically does not provide guidance that is clearly 100% for or against something and generally is averaging results for a large group of people so the “average” patient may not even exist in real life. Results might have been clustered at extremes, with a group that was helped and a group that was harmed by the research substance. The average statistic would be from the middle of both groups and might suggest that all people will be helped that middle amount of a little bit rather than that half the people may be helped a lot and half the people may be harmed a lot. People vary in their body’s ability to detoxify and in their body’s supply of nutrients available for detoxifying or for growth and repair. Evidence based medicine frequently looks at the averages of all patients rather than looking at individual results.

Preventative health guidance can suggest that something may help or may be more harmful ,but on an individual basis a health suggestion can not be guaranteed to prevent ADHD or autism in every case, anymore than vaccinations can be guaranteed to be safe for every individual or to never have been associated with autism as an adverse reaction in a few individuals. Vaccinations have been associated with encephalitis as an adverse reaction that leads to autism like symptoms over time.

Rates that are increasing exponentially are likely to plateau or slow down at some point but do we really want to find out how much worse an exponential rate can get before trying to do something about it? Autism used to occur at a rate of about 4.5 children in 10,000 just a few decades ago (1966), in 1994 the rate was as high as 15-40 children per 10,000, and now it is somewhere closer to 1 child in 68 or 1 child in 45 depending on which study or group of children you’re looking at. In 2012 the rate was 1 child in 88.

Excerpt:

Clinicians can identify ASD in children as young as two years old, although children from ethnic minority groups are usually diagnosed at a later age than their Caucasian counterparts. ASD is commonly comorbid with attention-deficit hyperactivity disorder, anxiety disorders, intellectual disability, epilepsy and other genetic conditions like fragile X syndrome, tuberous sclerosis, neurofibromatosis, congenital rubella syndrome, Down syndrome, Prader-Willi syndrome, and Angelman syndrome. Until recently, there was little, if any, epidemiological research focusing on the prevalence of ASD in adults. In 2011, one study reported the prevalence of ASD in an adult sample to be 1%, with higher rates for men (1.8%) than women (0.2%) (Brugha T et al, Arch Gen Psych 2011;68:459–466).

Similarly, there are few studies evaluating outcomes and prognosis for adults with ASD. Given current prevalence rates, the population of adults with autism is expected to rise 625% by the year 2030, and the estimated lifetime cost per individual with autism, including caregiving costs and lost productivity, can reach up to $3.2 million (Ganz M, Arch Ped Adol Med 2007;161(4):343–354).

White male children seem to be the group most at risk for developing autism, currently, and Asian children may be the group least at risk (the iodine content in sea weed may be a protective dietary factor and rice may have less risk of having the pesticides that are suspected of being neurodevelopmental toxins than wheat or corn).

The 2010 U.S. census showed a total of 138,053,563 males (49.1% of total population) and 143,368,343 females (50.9% of 281,421,906 total population). http://www.infoplease.com/us/census/data/demographic.html

If approximately 1.8% of adult men have autism and 0.2% of women have autism that would mean approximately 2,484,964 men and 286,736 women may have autism (2,771,700 total) and which might cost up to  $8,869,440,000,000 dollars in lifetime caregiving costs and lost productivity (almost 9 trillion dollars) — and that estimate would just be for the 2010 total. The rate of autism occurrence has increased since 2010. If the rate increases 625% by 2030 then we may expect 17,323,125 adults to have autism at a cost up to $55,434,000,000,000 in caregiving and lost productivity costs (55 trillion dollars)(and approximately 90% would be males, 15,590,812, (with a 1.8% incidence rate) and 10% females, 1,732,312 (with an 0.2% incidence rate)).

Males are more at risk and white males in particular are at greater risk for developing autism. Female hormones may be helping protect the female infants brain development or a milder form with less behavior changes may not be being diagnosed based on the current diagnostic criteria. If we would like infants to have traditional health expectations in the future then it might be worth considering that the baby factories (pregnant women) are malfunctioning at increasing rates, (autism seems to be set up during the prenatal stage that flairs up in the child later in life), and with a personal cost of increasing rates of autoimmune disease (one in nine women of childbearing years are estimated to be diagnosed with some type of autoimmune disease – (see excerpt below). Glyphosate may be inhibiting the ability to activate vitamin D which is essential for the pregnancy and the baby’s development and the woman’s autoimmune risk. Taking Vitamin D supplements can be great but expected benefits might not be seen if the CYP enzymes necessary for activating the vitamin aren’t functional due to glyphosate.

Iodine, zinc, and folate and B12 deficiencies during pregnancy also seem to be involved in increased risk of autism developing in the child later in life. And vitamin D is involved in autoimmune disease risk. Vitamin D receptors work within the immune system and help the body to be less allergic to self or for the mother to be sensitized to the expected infant’s DNA. Low vitamin D in the mother could be increasing her risk for autoimmune disease later in life (microchimerism – a few cells with infant’s DNA in the mother or cells with maternal DNA in the infant may be involved in autoimmune antibodies developing) and increasing the infant’s risk for developing autism later in life. Just giving more vitamin D might not be helping as expected if the herbicide glyphosate is inhibiting the enzymes necessary for activation of the vitamin.

Depending on which diseases are called autoimmune disease, minimally 23.5 million people in the U.S. have some type of autoimmune disease. Excerpt:

Or slice these statistics another way: while one in 69 women below the age of fifty will be diagnosed with breast cancer, according to estimates, as many as one in nine women of childbearing years will be diagnosed with an autoimmune illness, which strike three times as many women as men — and most often strike patients in their prime. According to the National Institutes of Health, autoimmune disease affects far more patients than the 9 million Americans who have cancer and the 16 million with coronary disease.

Rates of type 1 diabetes are perhaps the most telling. Data over the past forty years show that type 1 diabetes, a disease in which immune cells attack the insulin-producing beta cells in the pancreas, has increased fivefold. The story regarding childhood-onset type 1 diabetes is more disturbing. Studies show that the number of children with type 1 diabetes is skyrocketing, with rates increasing 6 percent a year in children four and under and 4 percent in children aged 10 to 14.

Type 1 diabetes researchers insist that today’s rapid rise in this disease cannot be explained by either better diagnostics or by more people suddenly becoming genetically susceptible to type 1 diabetes; rather, a change in environmental factors is the “more plausible explanation.”

The average patient with autoimmune disease sees six doctors before attaining a correct diagnosis. Recent surveys conducted by the American Autoimmune Related Diseases Association reveal that 45 percent of patients with autoimmune diseases have been labeled hypochondriacs in the earliest stages of their illnesses. Some of this, no doubt, has to do with the fact that 75 percent to 80 percent of autoimmune disease sufferers are women, who are more easily dismissed by the medical establishment when hard-to-diagnose symptoms arise. In half of all cases, women with autoimmune disease are told there is nothing wrong with them for an average of five years before receiving diagnosis and treatment. Patients — most especially women — are often left feeling both confused and marginalized, or worse, labeled as psychosomatic malingerers.

http://www.alternet.org/story/80129/the_autoimmune_epidemic%3A_bodies_gone_haywire_in_a_world_out_of_balance

Also from that article: the rates of autoimmune disease have been increasing in many industrialized countries, not just the U.S.. And autoimmune disease seems to be more associated with living in urban areas than rural ones. Rates of Type 1 diabetes in children under four years old  has increased six percent and four percent for older children — that is just not right, not traditional, and not fair to our children or their future world. They will have to take insulin shots for the rest of their  (potentially shorter than expected) lives.

If glyphosate inhibits CYP enzymes then it may be affecting the pancreas as CYP enzymes play a role in detoxifying toxins within the pancreas. Chronic pancreatitis and pancreatic cancer may be associated with malfunction of CYP enzymes in the pancreas.  http://www.flandershealth.us/chronic-pancreatitis/the-role-of-enzymes-in-pancreatic-diseases.html

Inhibition of the CYP enzymes might not be involved though, another reference suggests the CYP enzymes in the pancreas of patients with chronic pancreatitis or pancreatic cancer are elevated — but maybe the levels are elevated because the enzymes are not functioning as normal and the body may be making extra to try to compensate for the malfunction – we don’t know what we don’t know until we learn it or admit that we already learned it a long time ago but have been in denial.  https://books.google.com/books?id=J38lUlOxgoEC&pg=PA143&lpg=PA143&dq=CYP+enzymes+role+in+the+pancreas&source=bl&ots=EMkv-013SF&sig=ONq1DMQh6NaVs3uZc77Ay9cKHL0&hl=en&sa=X&ved=0ahUKEwjsqZ6G1NzNAhXE2R4KHaWLBAAQ6AEIJTAB#v=onepage&q=CYP%20enzymes%20role%20in%20the%20pancreas&f=false


/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./