Oxidative Stress and Aging; trace minerals and antioxidants

For a more detailed review of the current understanding of how oxidative stress and inflammation are involved in the aging process see this chapter from a longer book: Oxidative Stress and the Aging Brain: From Theory to Prevention, [1]

Mitochondria are the main energy producers in cells. They are involved in breaking down each molecule of glucose (one half of the larger molecule that is commonly known as sugar). During the process of breaking the chemical bonds found in the glucose molecule the free radicals that can cause oxidative damage are produced. When adequate antioxidants are available the free radicals are stabilized before they can cause damage. The body’s internally produced antioxidant enzymes also require the trace minerals copper, zinc and manganese. /Separate topic: An imbalance in copper and zinc can cause health problems./

“Free radicals are chemical species with a single unpaired electron. The unpaired electron is highly reactive as it seeks to pair with another free electron; this results in the production of another free radical. The newly produced free radical is unstable in most cases and, as a result, it can also react with another molecule to produce yet another free radical. Thus, a chain reaction of free radicals can occur, leading to more and more damaging reactions.” [1]

“Several antioxidant defense mechanisms have evolved to protect cell components from the attack of oxidative stress and associated oxidative damage. These mechanisms include antioxidant enzymes, such as SOD, superoxide reductases, catalase, glutathione peroxidases (Gpx), and many heat-shock proteins.” “SOD exists in two forms: Cu/ZnSOD is present primarily in the cytoplasm while MnSOD is present primarily in the mitochondria.” [1]

More information about manganese superoxide dismutase (MnSOD) and how mitochondria function is available here: MnSOD in Oxidative Stress Response-Potential Regulation viaMitochondrial Protein Influx [2]

Supplementing the diet with a manganese and other trace minerals may be helpful as manganese and other trace minerals may be chelated by glyphosate, the active ingredient of the herbicide RoundUp. Chelation is a chemical term for the tendency for one chemical to bind with another – take hold and make the other one less freely available in the environment. The process can be helpful in some situations as it can act as a carrier, a taxi cab so to speak, but at other times it is simply removing the other chemical from being available for other uses.

Plant scientists are aware of the problem and there are agricultural suggestions for reducing the negative effects of manganese chelation by glyphosate in the following article: What About Glyphosate-Induced Manganese Deficiency? The effects of glyphosate’s chelation of iron, copper and zinc is also included in addition to the discussion of manganese. [3] The summary of plant yield research found that improved crop yields were produced when manganese, copper and zinc were applied as a supplemental fertilizer a certain amount of time after the glyphosate containing herbicide was applied to the fields:

“The greatest soybean yield response on high organic soils
was with both Mn and Cu applied 8 to 12 days after the glyphosate.
The highest yields for corn were obtained by foliar-applying Zn 15
days after glyphosate was applied in northwestern Indiana,” [3]

So if plant health scientists recommend supplementing with manganese, copper and zinc for best plant health do human health scientists? Some do, but the topic is still considered alternative medicine rather than being a mainstream medical recommendation. [4] Risks of increased toxicity from trace metals that have negative health effects such as aluminum. [4]

Antioxidant rich foods or supplements that were discussed in the chapter on Oxidative Stress and Aging include vitamin E, which had positive results when used as a supplement in animal studies and mixed results in studies with humans, addition of whole foods such as nuts which are a good source of vitamin E and other nutrients had more consistent positive results in human clinical research studies; Green Tea and its active metabolite EGCG; blueberries, spinach and spirulina, a blue-green algae. [1]

  • Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
  1. Carmelina Gemma, Jennifer Vila, Adam Bachstetter, and Paula C. Bickford, Chapter 15: Oxidative Stress and the Aging Brain: From Theory to Prevention, from Brain Aging: Models, Methods, and Mechanisms. Riddle DR, editor. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. https://www.ncbi.nlm.nih.gov/books/NBK3869/
  2. Demet Candas and Jian Jian Li, MnSOD in Oxidative Stress Response-Potential Regulation viaMitochondrial Protein Influx, Antioxid Redox Signal. 2014 Apr 1; 20(10): 1599–1617. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942709/
  3. Don M. Huber, What About Glyphosate-Induced Manganese Deficiency?, Fluid Journal, Fall 2007, http://www.agweb.com/assets/import/files/58p20-22.pdf
  4. Anthony Samsel and Stephanie Seneff, Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies, Surg Neurol Int. 2015; 6: 45. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/

Glyphosate was found in vaccines; and tips for reducing dietary exposure

The nonprofit organization Moms Across America paid to have five types of vaccines tested in an accredited laboratory for the presence of the herbicide glyphosate. The chemical, which was originally patented as an antibiotic and mineral chelator, has never been tested or marketed as an injectable drug. Vaccines are injected directly into the blood stream which bypasses the protection of the gastrointestinal system.

The World Health Organization has advised that glyphosate is a probable carcinogen and it may affect hormones which would make it dangerous potentially for pregnant women and their expected infants:

“Honeycutt continues, “The public must know that their vaccines likely contain glyphosate, a toxic weed killer, which is acknowledged by the EPA as a “reproductive effector” ( i.e.: endocrine disruptor) which “can cause liver and kidney damage” and has been shown to be a neurotoxin. The WHO has deemed glyphosate a probable carcinogen.” – Moms Across America

The MMR II vaccine by the Merck company was found to have the highest level of glyphosate, 25 times more than what was found in the other four types of vaccines that were tested: “had levels up to 25 times higher than the other vaccines, at 2.671ppb.” The MMR II vaccine has been associated with autism as an adverse reaction (possibly due to an encephalitis reaction which then leads to the more extreme brain damage seen in patients with autism).

This supports the theory discussed by Professor Seneff, that glyphosate may be in vaccinations due to the use of animal products in the gelatin based Petri dishes in which the antigens for the vaccinations are grown. The theory suggests that glyphosate is similar enough to the amino acid glycine that it may be being built right into the protein structure of the animals body parts which include the collagen that is used to make gelatin. The glyphosate would be acting like a puzzle piece that kind of fits in one side of the protein but has the wrong shape on the other side of the puzzle piece so no other pieces of the puzzle can be added afterwards. One part of glyphosate would fit well into the protein structure but then another part wouldn’t be able to do what glycine does – which is donate methyl groups – which can help protect against cancer.

Some genetic canaries in the coal mine, such as myself, may have errors in the methylation cycle that disrupt the glycine function without needing any help from glyphosate. While filling my vitamin boxes for a week’s supply I was reminded that one of the supplements I added after getting my genetic methylation cycle results is . . . DMG . . . which is Dimethylglycine. I’ve been taking one of the capsules in the morning and one in the evening — but there is no guidance for how much of it I might need with my particular genetic defect.  My favorite phrase – or least favorite: “More research is needed.” Current information available suggests 2 grams of glycine per day may be a typical amount provided by the diet but ten times that amount may increase health benefits, no toxicity upper limit has been set; https://draxe.com/glycine/

Professor Seneff included tips for how to possibly reduce your exposure to glyphosate and some strategies that have been used on farm animals who were made sick by acute exposure to glyphosate.

Professor Seneff’s slides for her discussion lists”Some Important Nutrients“:

  • Curcumin
  • Garlic
  • Vitamin C
  • Probiotics
  • Methyl tetrahydrofolate – (this is the bioactive form of folic acid)
  • Cobalamin
  • Glutathione
  • Taurine
  • Epsom salt baths  [My how to tips for Epsom salt baths]

She also recommends:

  • Get Grounded” — ie work on general lifestyle and stress reduction strategies;
  • Eat organically grown foods whenever possible;
  • Eat foods containing the mineral manganese; (as glyphosate is a mineral chelator which may limit manganese’s availability for essential functions.) She mentions a few foods and shares an image which appears to include: organic whole grains, seeds, organic tofu and other beans, shellfish, tea, dark green leafy vegetables. This list provides more information — for example cardamom and pumpkin pie spice are sources of manganese:  http://nutritiondata.self.com/foods-000126000000000000000.html
  • Eat foods containing sulfur; (and/or take the Epsom salt baths which would supply magnesium and sulfur.) She mentions a few foods and shares an image which appears to include: beer, cabbage, organic eggs, especially the yolk, crab, shrimp and scallops, cheese, onions, garlic, organic liver, chicken, and something I’m not going to try to guess. Based on this list of the sulfur content of many foods the image may include a picture of dried apricots:  http://apjcn.nhri.org.tw/server/info/books-phds/books/foodfacts/html/data/data5g.html

Professor Seneff speaks very quickly, I may have missed some of her tips for trying to protect yourself from exposure to glyphosate.

She includes information about extracts from common plants that can treat glyphosate poisoning including:

Extracts from common plants such as dandelion, barberry, and burdock can protect from damage, especially if administered prior to exposure.”* (*C Gasnier et al. Journal of Occupational Medicine and Toxicology 2011, 6:3). [https://occup-med.biomedcentral.com/articles/10.1186/1745-6673-6-3]

And cows with glyphosate poisoning have been treated with:

Activated charcoal, bentonite clay, humic and fulvic acids, and sauerkraut juice have been shown to be effective in reducing glyphosate and improving animal health.“** (** H Gerlach et al., J Environ Anal Toxicol 2014, 5:2). [http://www.omicsonline.org/open-access/oral-application-of-charcoal-and-humic-acids-influence-selected-gastrointestinal-microbiota-2161-0525.1000256.pdf]

See the research papers for more detail and a functional medicine professional may be able to help guide individualized treatments with some of the items that are mentioned such as activated charcoal– but seek guidance, professional help is recommended even when using natural treatments.

/Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./