Why should we care about demyelination?

This post is a summary of two recent posts:

  • Good News/Bad News about Multiple sclerosis Research (7/26/2018) 
  • Demyelination, continued. (7/28/2018) 

Why Care about Demyelination? 

We need to care about demyelination as a society because it may be a factor underlying many conditions that have been occurring at increasing rates. The high cost of health care is not just due to the cost of individual medications or the price of hospitalization but is due to the additive cost of increased numbers of individuals needing care. Autism care alone is estimated to likely reach $500 billion by 2025 for care in the U.S. alone, (link), demyelination or disordered myelin formation is thought to be involved. Our food supply may provide calories but it may no longer be supporting health due to imbalance in some nutrients and lack of sufficient amounts of other nutrients – in addition to personal choices for some people leaning toward convenient and tasty foods that provide very few nutrients besides calories.

The other reason to care about demyelination as a society is because the early symptoms can occur for years without clear reasons and may disrupt relationships or the ability to hold a job – personality changes including anxiety and anger, paranoia and a short temper – problems with impulse control and the ability to follow through on planned actions or with communication and the ability to tell the truth instead of substituting other statements that may seem illogical and obviously far from the truth. Problems with impulse control and a tendency toward mood problems may also include an increased risk for suicide or self injury or violence towards others.

The medical research is complex and I haven’t seen all the loose threads together yet, so I will summarize my summary points in a more concise list here and am working on a more organized document elsewhere. This list combines my tips from the previous post with the work of the other summary article (22) — I was also given the link to another summary article which also has tips which I have not incorporated here. It provides an excellent overview about myelin production and function –selfhacked/myelin – what I and the authors of (22) and {selfhacked} have in common is that we all got sick and sought information about regaining our health for ourselves and are sharing the information in case it might help others.

My personal goal is to not become paralyzed (post: ALS & CBD receptors), number of clicks on a website is not something I pay attention to. The loose threads that I’ve woven together in this series of posts which are not included in the excellent selfhacked article are that a) many of the herbs or phytonutrients found helpful for myelin regeneration are Nrf2 promoting which is also important for myelin regeneration and/or reducing oxidative stress that may lead to more degeneration of myelin. b) Foods that are good for promoting Nrf2 often are also good sources of cannabinoids or phospholipids which can be protective. c) And preventing excessive cell death or excess intracellular calcium may decrease the excess production of cytokines by decreasing release of cannabinoids from cell membrane storage and their breakdown into arachidonic acid and eventual transformation into cytokines and other inflammatory chemicals.}: 

Strategies to help prevent the breakdown of myelin or help promote regeneration of myelin:

{In the past at different points in time, I personally have experienced and improved with supplementation or diet changes physical and mental symptoms of vitamin B1, B5, B6, folate and B12 deficiencies; iodine, magnesium, calcium and zinc deficiencies; vitamin/hormone D and calcium excess at a different stage of health;  cannabinoid/phospholipid deficiency; inadequate protein and general malnutrition due to the zinc deficiency which can greatly reduce appetite at one stage and due to severe bowel mal-absorption more recently; omega 3 fatty acid/omega 6 fatty acid imbalance; and also lack of sleep/melatonin and lack of oxygen/excess toxins in the air; health requires all of the nutrients and adequate oxygen, exercise, sleep and stress coping.}

  1. Vitamin B1, thiamin deficiency, chronic, severe – Wernicke’s encephalopathy may be more of a risk for severe alcoholics and people with anorexia – severe lack of appetite or the eating disorder anorexia nervosa. 
  2. Vitamin B12 deficiency – may be more of a risk for people with low stomach acidity, due to older age or chronic use of calcium type antacids; or due to genetic reasons limiting production of Intrinsic Factor; or due to a vegan diet without supplementation of vitamin B12 or inclusion of Nutritional yeast flakes in the diet. 
  3. Zinc deficiency (22) or copper  excess (link). 
  4. Adequate but not excessive lithium may increase myelin production. (22) 
  5. Adequate but not excessive iron intake is needed for production of myelin. 
  6. Magnesium deficiency or poor intestinal absorption of magnesium, or lack of adequate protein and phospholipids in the diet for the body to be able to store magnesium in the normal manner within the intracellular fluid. 
  7. Inadequate calcium or vitamin D can be a factor but excessive intake of either can also be a factor in cell breakdown and risk of demyelination. If taking vitamin D as a supplement the vitamin D3 form may be most bioactive and taking vitamin K2 with it may help with myelin production (22) and protect against osteoporosis. Green leafy vegetables are good sources of vitamin K. 
  8. Adequate intake of cholesterol is needed as a building block for our own production of vitamin D and other steroid hormones and as a building block for myelin. (22) Pregnenolone is a steroid hormone precursor that may benefit some people when used as a supplement. It and other steroid hormones are involved in signaling increased production of myelin. Testosterone insufficiency may also negatively affect myelin production. (22) 
  9. Excessive intake of free glutamate or aspartate – excitatory amino acids that are commonly used as flavoring or sweetening agents in foods or may occur naturally in fermented foods or alcoholic beverages. 
  10. Adequate protein is needed to support a variety of body functions in addition to supporting magnesium levels. Uridine is a nucleotide base (part of DNA that is a combination of a type of sugar and an amino acid) that is also is involved in energy metabolism, fasting occasionally may increase our own production (more info). Insufficient amounts may negatively affect myelin production and use as a supplement may help some people. (22) 
  11. Insufficient calories to provide the body enough glucose to support mitochondrial health. They can use protein or fats for energy but it shifts the metabolism more towards oxidative stress. 
  12. Occasional fasting and/or a low carbohydrate diet may help promote autophagy due to increased use of ketones for energy (22) but may cause health problems due to excess oxidative stress or an increased burden of nitrogen waste removal for the kidneys when followed long term. 
  13. Lack of antioxidants due to lack of Nrf2 within the body to promote our own production of antioxidants internally; and/or lack of antioxidants within the diet, including vitamin C, (22), would decrease our ability to detoxify the reactive oxidative chemicals produced during normal metabolism or which are produced at increased rates when protein or fats are being used for energy instead of glucose. 
  14. Use of the herb ashwagandha or Gingko biloba (22) may help protect against oxidative stress and protect against demyelination by promoting Nrf2. (ashwagandha & Nrf2) (an overview of Nrf2 metabolism, its potential benefits for conditions such as Multiple sclerosis, and Gingko biloba and pomegranate are mentioned as promoters of Nrf2: nutricology/newsletter, see first article) (other Nrf2 promoting phytonutrients/foods and menu ideas: G10: Nrf2 Promoting Foods.) Flavonoids are one of the groups of phytonutrients that helps promote Nrf2; and also may help protect myelin production. (22) Medicinal mushrooms, including Hericium Erinaceus, Lion’s Mane Mushroom,(22), may also help protect myelin production and prevent breakdown by reducing oxidative stress (link) and promoting Nrf2. (link) 
  15. Having a healthy balance of omega 3 fatty acids and omega 6 fatty acids in the diet helps reduce risk of inflammation/oxidative stress and also helps us build healthy membranes which are necessary to control flow of minerals and other chemicals from the exterior to interior of cells and organelles such as the mitochondria. 
  16. Inadequate iodine for healthy thyroid hormone production, (22); may be a combined problem of excess presence of bromide, fluoride and perchlorate in the diet or environment. 
  17. Lack of oxygen due to poor air quality, or smoking, or health problems causing inadequate breathing function. Emotional or physical stress may also increase the need for oxygen or increase the tendency to hold our breath; Take ten deep breaths and think before you speak is good advice for any emotionally stressful situation because oxygen is needed to think rationally and we tend to hold our breath when we are upset. 
  18. Avoid extreme physical and emotional stress. 
  19. Avoid toxins. 
  20. Get adequate sleep at night, and a brief nap during the day may be beneficial for some people. Melatonin helps promote myelin production and inadequate sleep and having lights on at night can disrupt our production of melatonin. (22) 
  21. Adequate exercise (22) and stretching regularly helps move nutrients throughout the body and remove toxins in the lymphatic fluid for further detoxification and eventual removal from the body. 
  22. Wear a helmet for any activity that may cause head trauma and avoid sports which may cause frequent closed head trauma and especially when helmets are not used (sorry soccer, football, hockey, (link), and boxing fans). 
  23. Adequate phospholipid and other phosphonutrients or cannabinoids may be necessary to include from external sources if genetic differences or other health problems or age interferes with the body’s internal production capability. Dark cocoa products, cardamom powder, pomegranate and pumpkin seeds are a few legal dietary sources. 
  24. Use of ibuprofen and/or ginger (approximately 1/2 teaspoon per day) may help prevent breakdown of our body’s supply of cannabinoids, breakdown of which may then lead to increased breakdown of cells and may then lead to increased degeneration of myelin. 
  25. Lack of any B vitamins or genetic differences in the ability to remethylate folate and vitamin B12 may disrupt the ability of mitochondria to generate usable energy from glucose or proteins and fats, and may reduce production of myelin. (22) Inositol and choline may be particularly important for myelin production. They are considered to be in the B vitamin group but was discovered more recently than the numbered series of B vitamins. (22) 
  26. Low Level Laser Therapy – I am not familiar with this, see #10: (22), but I have read elsewhere that certain types of light can stimulate activity levels. (Haier) 
  27. Practice, practice, practice – new things. (22) Myelin is produced in response to learning [45] so remaining mentally stimulated with new experiences and learning new topics or techniques keeps signalling the body to produce myelin.  
  28. Brain-derived Neurotrophic Factor, (BDNF), the brain’s growth factor, may help increase production of myelin by increasing production of brain cells, which include oligodendrocytes. (22) Ways to promote BDNF (link, from within 22) fortunately overlap with the strategies for protecting against demyelination already mentioned above or included in the list of Nrf2 promoting foods. 
  29. Reducing exposure to electromagnetic fields (EMF) – energy leakage from laptops, smartphones, WiFi, televisions, and other strong sources of electicity may help protect against myelin degeneration. (22) 

References and more details for some of this information were included in the last two posts:  

  • Good News/Bad News about Multiple sclerosis Research (7/26/2018) 
  • Demyelination, continued. (7/28/2018) 

/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./  

Pomegranate extract – Master Chef Challenge update

For anyone following along with the pomegranate peel experiments  (previous post)- update, I had a lot of pomegranate extract thawed at the same time and for a dietitian that means reheat to steaming to assure food safety. So it was an opportunity to experiment some more with trying to adjust the acidity again. When baking soda is added to a hot acidic liquid there is an obvious bubbling reaction and change in color of the liquid. I have pH strips to check acidity and did manage to adjust the acidity of the extract. The taste is still not great but chronic illness and mood issues are not great either. After three cups of experimental attempts my mood is awesome *(see additional note) and I have some recipe details:

6 cups of pomegranate extract  (previous post)

2 Tablespoons Cardamom powdered spice

1 teaspoon Gumbo File powdered spice (Sassafras Leaves, powdered and used in Gumbo’s in Creole style cooking)

1 teaspoon Baking Powder

  1. Add the Cardamom and Gumbo File to the Pomegranate Extract and stir well to break apart any dry lumps of the powdered spices. The Gumbo File acts as an emulsifier and is a digestive aid and the Cardamom adds flavor, phytonutrients and would help alkalize the mixture in addition to the alkalizing power of the Baking Soda.
  2. Bring the mixture to a boil.
  3. Add the Baking Soda and stir. Remove the mixture from the heat and keep stirring. It will froth up and stirring helps keep it from frothing over the top of the pan. The color changes from pinkish to brown from the Cardamom spice.
  4. To drink as a beverage dilute with equal parts water to Pomegranate Extract.

This would be an acquired taste – aka “not good” until you get used to it, or not good at all but the mood and health benefits are worth for me at least. It is also a diuretic which means it is like beer or coffee in the way it increases kidney activity and urine production so it is best to have it earlier in the day followed by plenty of glasses of water early in the day so that you aren’t waking up in the middle of the night as much. Overly acidic, dehydrated body fluids can increase work for the kidneys and result in a frequent feeling of needing to go urgently but then not producing much quantity – drink plenty of water early  in the day and produce plenty of dilute quantity early in the day and a diuretic can help cleanse toxins from the body instead of being a middle of the night problem.

Since pomegranate growing season is limited the powdered spice made from Sumac might be a health substitute. It has been shown to have a range of health benefits, and is also a diuretic. Its phytonutrients are similarly colored suggesting there might be some similar antioxidant content as well. The gallotannin group of phytonutrients are in common and would likely promote Nrf2. (More about Sumac in this post) (a series of posts on Nrf2)

To put a financial perspective on this – for my health needs the pomegranate extract or pomegranate seeds and cardamom powder and a few other good sources of phospholipids are adequate replacements for my medical marijuana which cost me around $1000-1200 per month. The medical effects are slightly different and not quite as good for pain killing properties but the negative psychological effects that can occur with withdrawal for some people are also not present.

To review – cannabinoids are a group of chemicals that are made within the cells of most species and are similar to the group of cannabinoids found in the cannabis plants commonly known as marijuana or hemp. Medical marijuana has a euphoria producing one known by the chemical initials THC while hemp has only non-euphoria producing cannabinoids. Both types can have medical or other basic health benefits. Cannabinoids are found throughout membranes and add to cell wall flexibility and help with messenger chemical type activities that can help reduce inflammation and fight infection. Some people such as myself can have genetic differences that make it impossible to make the chemicals internally as in average health. I have had minor health problems since infancy and having external dietary sources of phospholipids or cannabinoids helps my body and mood and immune system. More information about the topic is available in the post/article Is it Addiction or Starvation?

People with problems with binge eating disorders, alcohol abuse tendencies, meth or heroin/opioid abuse tendencies, or seem to have an excess use of marijuana, and nicotine to a lesser extent all may actually have underlying genetic differences that leave them in need of increased dietary sources of phospholipids/cannabinoids. The article Is It Addiction or Starvation? has some legal food sources in addition to pomegranate seeds and cardamom spice. It doesn’t mention the Middle Eastern spice Sumac but it might help also.

*Additional note – three cups was likely to large of a serving, an awesome mood for someone with unstable mood issues was too much of a good thing – Newton’s Law of Gravity may apply metaphorically, “What goes up must come down.” I had a worse mood problem later in the evening. Today (the next morning) I’ve enjoyed a few spoonfuls of the spicy, creamy slightly thickened mixture in my coffee and it is good to my “acquired taste.” The thing about having acquired an acquired taste for something is that you then want to acquire more – pun intended.  The pomegranate season in Australia turns out to also be November to March so that isn’t much help. Processing pomegranate peel during the growing season would be necessary if I hope to continue to be able to acquire pomegranate extract all year long. It has medicinal benefits according to the research that is available, (see links in earlier posts on this site).

New Zealand isn’t ideal for pomegranate either as the summer length may be too short some years, however their harvest season is February-April: “Pomegranates grow best in areas with cold Winters and long hot, dry Summers.” (Pomegranate Wonderful)

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

For those who can’t grow pomegranates, consider sumac instead

Sumac is a shrub like tree or a tree like shrub that is an invasive plant in many areas. Types that have white berry clusters should be avoided as the white berries are poisonous but the types with clusters of red berry like seeds are safe to consume when made into a tea and they may be dried and ground into a spice. Native Americans use them in a lemonade like beverage and they are ground into a spice which is used in many Middle Eastern dishes and as a table condiment to sprinkle on foods to individual taste. The ground Sumac is mixed with salt or available plain in shaker bottles and is mixed with a few other spices in the blend called za’atar (sesame seed, salt, and thyme or hyssop).

Some of the phytonutrient content and medicinal properties  of edible sumac are similar to those found in pomegranate and may be associated with the bright red pigmentation. The botanical name for Sumac , ‘Rhus,’ translated as a foreign word means ‘red.’ Some people may be allergic skin reactions from touching the plant in nature (1) and as a more concentrated tea it has diuretic properties, which can have health benefits to help remove toxins if plenty of additional water is also consumed to prevent dehydration. (2)

Sumac is used medicinally in Arab countries. Studies on sumac extracts to date have indicated that the plant may be a source of bioproducts with the following bioactivities: antifibrogenic, antifungal, anti-inflammatory, antimalarial, antimicrobial, antimutagenic, antioxidant, antithrombin, antitumorigenic, antiviral, cytotoxic, hypoglycaemic and leukopenic (Rayne and Mazza, 2007).” (1)

The lemonade like flavor would be from the terpene limonene and possibly other terpenes found in the plant. Anthocyanins likely give it some of the bright color. It also contains tannins primarily in the form of gallotannins, which are similar to the elligatannins/ellagic acid found in pomegranate, (3), and other aldehydes and beneficial acids that give it tartness including vitamin C – ascorbic acid. (1) Eating a large enough amount on a regular basis may be important for the health benefits from phytonutrients. Research with elligatannins has found them helpful for cancer prevention and somewhat for treatment (4) but a recent study that used a small dose, 900 mg of pomegranate extract per day, found some changes in important genes but not conclusive health benefits. (5) Research on tumor inhibiting properties of sumac found it beneficial during early stages when the tumor is developing rather than as a treatment after it was formed (animal study). (6) Animal based trials in more recent research that found benefits using pomegranate extract used doses that would be equivalent to larger doses, 1 to 10 grams/kilogram body weight per day. The study and amounts used are discussed in this post and the link is in this earlier post. A beneficial substance that we have to make for ourselves, Nrf2 may be involved. Tannins, anthocyanins, and aldehydes were all mentioned as being helpful for helping promote our own body’s ability to produce more Nrf2. The gallic acid (related chemically to the gallotannins, the mango fruit is also a source (8)) is mentioned to help induce apoptosis in cancer cells (cell death) in an article discussing the role of oxidative stress in cancer treatment. (7)

“Gallic acid (3,4,5-trihydroxybenzoic acid, GA), a polyhydroxy phenolic compound, is abundant in natural plants such as gallnut, grapes, sumac, oak bark, green tea apple peels, grapes, strawberries, pineapples, bananas, lemons, and in red and white wine. Its antioxidative DNA-damage action has been well documented []. However, gallic acid induces apoptosis in several cancer cell lines by increasing ROS level and GSH depletion [].” (7)

That excerpt is from a section titled: 5.1. Anticancer ROS-Generating Compounds from Natural Origin(7), which also contains information on other phytonutrients and foods that contain them that have been found beneficial for preventing or treating cancer or reducing oxidative stress.

I bought some dried sumac prepared for table use but chose a brand without salt added to it so I could use as much as I want without having to be concerned about adding too much salt. The aroma and flavor are good and the color is very pretty, slightly more purplish than paprika but similar in the bright addition it makes when sprinkled on the surface of a food. It was $3.99 for a 9.33 ounce bottle at a Middle Eastern foods grocery store.

Phytonutrients with bright colors often seem to be associated with health benefits but that doesn’t mean all wild berries or plants are edible. Read guides and know what you’re harvesting before eating it – and avoid private property and nature preserves where it might be illegal to pick anything.

They are so common in some areas that I happen to have picture taken on a recent walk. A discussion with more detail and a close up image taken during late summer is available here: The ‘Lemonade Tree’: It’s Time to Harvest Sumac, EdibleEastEnd.com. (2)

Wild sumac seed pod in wintertime.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

  1. Sumac – an overview, ScienceDirect Topics, sciencedirect.com,   https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/sumac
  2. Ronald Halweil, The ‘Lemonade Tree’: It’s Time to Harvest Sumac, Edible East End, August 9, 2012, EdibleEastEnd.com,   https://www.edibleeastend.com/2012/08/09/harvest-sumac/
  3. J. P. PerchelletH. U. GaliE. M. PerchelletP. E. LaksV. BottariR. W. Hemingway, and A. ScalbertAntitumor-Promoting Effects of Gallotannins, Ellagitannins, and Flavonoids in Mouse Skin In Vivo
    Food Phytochemicals for Cancer Prevention, Chapter 25, pp 303–327
    Chapter DOI: 10.1021/bk-1994-0546.ch025, ACS Symposium Series, Vol. 546, http://pubs.acs.org/doi/abs/10.1021/bk-1994-0546.ch025
  4. Tariq Ismail, Cinzia Calcabrini, Anna Rita Diaz, Carmela Fimognari, Eleonora Turrini, Elena Catanzaro, Saeed Akhtar, and Piero Sestili,

    Ellagitannins in Cancer Chemoprevention and Therapy. Toxins (Basel). 2016 May; 8(5): 151. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885066/

  5. Nuñez-Sánchez MA, González-Sarrías A, García-Villalba R, et al, Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. J Nutr Biochem. 2017 Apr;42:126-133. doi: 10.1016/j.jnutbio.2017.01.014. Epub 2017 Jan 27.    https://www.ncbi.nlm.nih.gov/pubmed/28183047
  6. Perchellet, J.P., Gali, H.U.Perchellet, E.M.Laks, P.E.et al., Antitumor-promoting effects of gallotannins, ellagitannins, and flavonoids in mouse skin in vivo  [1994], ACS symposium series, ISSN : 0097-6156, Source: Information Systems Division, National Agricultural Library, http://agris.fao.org/agris-search/search.do?recordID=US9602151

  7. Giuseppina Barrera, Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy., ISRN Oncol. 2012; 2012: 137289.  
       https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483701/
  8. Gallotannins, Science Direct, ScienceDirect.com,   https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gallotannins

Why care about health? It’s about statistics.

The rate of cancer incidence has increased greatly in many countries and is expected to continue to increase, particularly in association with the aging of the population. Cancer is more often a diagnosis after age 65.  The rate of thyroid cancer in particular has increased greatly in women. The rate of developing some type of cancer during one’s lifetime is expected to reach 1 in 2 men and 1 in 3 women by the yea 2050, (MedScape) – or a more general 1 in 2 people, (medicalnewstoday) – those are not good odds.

It is common during youth to feel secure about health but our bodies tend to run out of stored nutrients as we age and metabolic pathways that we depend on to rebuild muscle and remove toxins or defective cells can become less effective. A healthy immune system also protects us from our own body’s normal rebuilding/regrowth of new cells. Defective ones are typically removed from growth areas in bone marrow before they enter circulation. Cancer cells are also removed on a regular basis when our immune systems are healthy.

Magnesium deficiency is a topic I keep stressing because the immune cells require magnesium in order to perform the apoptosis, killing, of defective or precancerous cells. The body’s defense systems are well developed but need fuel on a daily basis in order to be able to function as nature designed. While immune cells need magnesium in order to purposefully kill defective cells by apoptosis ( an enzyme is inserted into the cell which causes it to die and then the immune cell engulfs the debris and removes it for detoxification and excretion from the body), a cell that is deficient in magnesium or calcium may also undergo apoptosis due to the deficiency. (magnesium and apoptosis)

Too little Nrf2 may reduce immune system and antioxidant health but too much can be a problem in cancer cells that grow too rapidly. (Nrf2 overproduction and cancer)

Another person writing about the recent research in the area of Nrf2 shares more information about foods that help promote Nrf2 and how nature may have built in a mechanism within some foods that help prevent an over production of the important protein (Nrf2). See: “Activate Nrf2, then optimize: Brussel Sprouts.” – Bill Lagokos (patreon) /Spoiler, if not a fan of Brussel Sprouts the healthy phytonutrient that is discussed is also found in cruciferous vegetables including cabbage, cauliflower, broccoli, kohlrabi, and kale.

I personally am more sensitive to the group, especially if served raw or in larger quantities, but find steamed kale everyday tolerable to my digestive system. The bloating effect may be due to our good guy bacteria enjoying the fiber rich vegetables so much they produce the excess gas – but it can be a sign of healthy bacteria in our digestive tract. Irritable Bowel Syndrome can be affected by any food that causes bloating effects possibly due to TRP channel’s being activated by increased pressure. People with a history of IBS and other chronic pain syndromes may be suffereing from an underlying issue with overactive TRP ion channels. IBS and TRP channels are discussed on this site in a previous post. TRP channels are discussed in more detail with links on another website: Chronic Itch, migraines, IBS and stress; – that is one part frm a longer series: Relaxation and Stress, which is continued in:  Preeclampsia & TRP Channels.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.