oxidative stress – Effective Self Care info

July 28, 2018August 1, 2018

Why should we care about demyelination?

This post is a summary of two recent posts:

Good News/Bad News about Multiple sclerosis Research (7/26/2018)
Demyelination, continued. (7/28/2018)

Why Care about Demyelination?

We need to care about demyelination as a society because it may be a factor underlying many conditions that have been occurring at increasing rates. The high cost of health care is not just due to the cost of individual medications or the price of hospitalization but is due to the additive cost of increased numbers of individuals needing care. Autism care alone is estimated to likely reach $500 billion by 2025 for care in the U.S. alone, (link), demyelination or disordered myelin formation is thought to be involved. Our food supply may provide calories but it may no longer be supporting health due to imbalance in some nutrients and lack of sufficient amounts of other nutrients – in addition to personal choices for some people leaning toward convenient and tasty foods that provide very few nutrients besides calories.

The other reason to care about demyelination as a society is because the early symptoms can occur for years without clear reasons and may disrupt relationships or the ability to hold a job – personality changes including anxiety and anger, paranoia and a short temper – problems with impulse control and the ability to follow through on planned actions or with communication and the ability to tell the truth instead of substituting other statements that may seem illogical and obviously far from the truth. Problems with impulse control and a tendency toward mood problems may also include an increased risk for suicide or self injury or violence towards others.

The medical research is complex and I haven’t seen all the loose threads together yet, so I will summarize my summary points in a more concise list here and am working on a more organized document elsewhere. This list combines my tips from the previous post with the work of the other summary article (22) — I was also given the link to another summary article which also has tips which I have not incorporated here. It provides an excellent overview about myelin production and function –selfhacked/myelin – what I and the authors of (22) and {selfhacked} have in common is that we all got sick and sought information about regaining our health for ourselves and are sharing the information in case it might help others.

My personal goal is to not become paralyzed (post: ALS & CBD receptors), number of clicks on a website is not something I pay attention to. The loose threads that I’ve woven together in this series of posts which are not included in the excellent selfhacked article are that a) many of the herbs or phytonutrients found helpful for myelin regeneration are Nrf2 promoting which is also important for myelin regeneration and/or reducing oxidative stress that may lead to more degeneration of myelin. b) Foods that are good for promoting Nrf2 often are also good sources of cannabinoids or phospholipids which can be protective. c) And preventing excessive cell death or excess intracellular calcium may decrease the excess production of cytokines by decreasing release of cannabinoids from cell membrane storage and their breakdown into arachidonic acid and eventual transformation into cytokines and other inflammatory chemicals.}:

Strategies to help prevent the breakdown of myelin or help promote regeneration of myelin:

{In the past at different points in time, I personally have experienced and improved with supplementation or diet changes physical and mental symptoms of vitamin B1, B5, B6, folate and B12 deficiencies; iodine, magnesium, calcium and zinc deficiencies; vitamin/hormone D and calcium excess at a different stage of health; cannabinoid/phospholipid deficiency; inadequate protein and general malnutrition due to the zinc deficiency which can greatly reduce appetite at one stage and due to severe bowel mal-absorption more recently; omega 3 fatty acid/omega 6 fatty acid imbalance; and also lack of sleep/melatonin and lack of oxygen/excess toxins in the air; health requires all of the nutrients and adequate oxygen, exercise, sleep and stress coping.}

Vitamin B1, thiamin deficiency, chronic, severe – Wernicke’s encephalopathy may be more of a risk for severe alcoholics and people with anorexia – severe lack of appetite or the eating disorder anorexia nervosa.
Vitamin B12 deficiency – may be more of a risk for people with low stomach acidity, due to older age or chronic use of calcium type antacids; or due to genetic reasons limiting production of Intrinsic Factor; or due to a vegan diet without supplementation of vitamin B12 or inclusion of Nutritional yeast flakes in the diet.
Zinc deficiency (22) or copper excess (link).
Adequate but not excessive lithium may increase myelin production. (22)
Adequate but not excessive iron intake is needed for production of myelin.
Magnesium deficiency or poor intestinal absorption of magnesium, or lack of adequate protein and phospholipids in the diet for the body to be able to store magnesium in the normal manner within the intracellular fluid.
Inadequate calcium or vitamin D can be a factor but excessive intake of either can also be a factor in cell breakdown and risk of demyelination. If taking vitamin D as a supplement the vitamin D3 form may be most bioactive and taking vitamin K2 with it may help with myelin production (22) and protect against osteoporosis. Green leafy vegetables are good sources of vitamin K.
Adequate intake of cholesterol is needed as a building block for our own production of vitamin D and other steroid hormones and as a building block for myelin. (22) Pregnenolone is a steroid hormone precursor that may benefit some people when used as a supplement. It and other steroid hormones are involved in signaling increased production of myelin. Testosterone insufficiency may also negatively affect myelin production. (22)
Excessive intake of free glutamate or aspartate – excitatory amino acids that are commonly used as flavoring or sweetening agents in foods or may occur naturally in fermented foods or alcoholic beverages.
Adequate protein is needed to support a variety of body functions in addition to supporting magnesium levels. Uridine is a nucleotide base (part of DNA that is a combination of a type of sugar and an amino acid) that is also is involved in energy metabolism, fasting occasionally may increase our own production (more info). Insufficient amounts may negatively affect myelin production and use as a supplement may help some people. (22)
Insufficient calories to provide the body enough glucose to support mitochondrial health. They can use protein or fats for energy but it shifts the metabolism more towards oxidative stress.
Occasional fasting and/or a low carbohydrate diet may help promote autophagy due to increased use of ketones for energy (22) but may cause health problems due to excess oxidative stress or an increased burden of nitrogen waste removal for the kidneys when followed long term.
Lack of antioxidants due to lack of Nrf2 within the body to promote our own production of antioxidants internally; and/or lack of antioxidants within the diet, including vitamin C, (22), would decrease our ability to detoxify the reactive oxidative chemicals produced during normal metabolism or which are produced at increased rates when protein or fats are being used for energy instead of glucose.
Use of the herb ashwagandha or Gingko biloba (22) may help protect against oxidative stress and protect against demyelination by promoting Nrf2. (ashwagandha & Nrf2) (an overview of Nrf2 metabolism, its potential benefits for conditions such as Multiple sclerosis, and Gingko biloba and pomegranate are mentioned as promoters of Nrf2: nutricology/newsletter, see first article) (other Nrf2 promoting phytonutrients/foods and menu ideas: G10: Nrf2 Promoting Foods.) Flavonoids are one of the groups of phytonutrients that helps promote Nrf2; and also may help protect myelin production. (22) Medicinal mushrooms, including Hericium Erinaceus, Lion’s Mane Mushroom,(22), may also help protect myelin production and prevent breakdown by reducing oxidative stress (link) and promoting Nrf2. (link)
Having a healthy balance of omega 3 fatty acids and omega 6 fatty acids in the diet helps reduce risk of inflammation/oxidative stress and also helps us build healthy membranes which are necessary to control flow of minerals and other chemicals from the exterior to interior of cells and organelles such as the mitochondria.
Inadequate iodine for healthy thyroid hormone production, (22); may be a combined problem of excess presence of bromide, fluoride and perchlorate in the diet or environment.
Lack of oxygen due to poor air quality, or smoking, or health problems causing inadequate breathing function. Emotional or physical stress may also increase the need for oxygen or increase the tendency to hold our breath; Take ten deep breaths and think before you speak is good advice for any emotionally stressful situation because oxygen is needed to think rationally and we tend to hold our breath when we are upset.
Avoid extreme physical and emotional stress.
Avoid toxins.
Get adequate sleep at night, and a brief nap during the day may be beneficial for some people. Melatonin helps promote myelin production and inadequate sleep and having lights on at night can disrupt our production of melatonin. (22)
Adequate exercise (22) and stretching regularly helps move nutrients throughout the body and remove toxins in the lymphatic fluid for further detoxification and eventual removal from the body.
Wear a helmet for any activity that may cause head trauma and avoid sports which may cause frequent closed head trauma and especially when helmets are not used (sorry soccer, football, hockey, (link), and boxing fans).
Adequate phospholipid and other phosphonutrients or cannabinoids may be necessary to include from external sources if genetic differences or other health problems or age interferes with the body’s internal production capability. Dark cocoa products, cardamom powder, pomegranate and pumpkin seeds are a few legal dietary sources.
Use of ibuprofen and/or ginger (approximately 1/2 teaspoon per day) may help prevent breakdown of our body’s supply of cannabinoids, breakdown of which may then lead to increased breakdown of cells and may then lead to increased degeneration of myelin.
Lack of any B vitamins or genetic differences in the ability to remethylate folate and vitamin B12 may disrupt the ability of mitochondria to generate usable energy from glucose or proteins and fats, and may reduce production of myelin. (22) Inositol and choline may be particularly important for myelin production. They are considered to be in the B vitamin group but was discovered more recently than the numbered series of B vitamins. (22)
Low Level Laser Therapy – I am not familiar with this, see #10: (22), but I have read elsewhere that certain types of light can stimulate activity levels. (Haier)
Practice, practice, practice – new things. (22) Myelin is produced in response to learning [45] so remaining mentally stimulated with new experiences and learning new topics or techniques keeps signalling the body to produce myelin.
Brain-derived Neurotrophic Factor, (BDNF), the brain’s growth factor, may help increase production of myelin by increasing production of brain cells, which include oligodendrocytes. (22) Ways to promote BDNF (link, from within 22) fortunately overlap with the strategies for protecting against demyelination already mentioned above or included in the list of Nrf2 promoting foods.
Reducing exposure to electromagnetic fields (EMF) – energy leakage from laptops, smartphones, WiFi, televisions, and other strong sources of electicity may help protect against myelin degeneration. (22)

References and more details for some of this information were included in the last two posts:

Good News/Bad News about Multiple sclerosis Research (7/26/2018)
Demyelination, continued. (7/28/2018)

/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./

January 8, 2018

Revisiting superstition from the perspective of economics

What do imaginary goods, virtual cats and superstition have to do with each other? – Economics. ‘Imaginary goods’ is a term used by an Austrian economic theorist from the 1800’s, Carl Menger, to describe goods that might be sold but which did not meet all the criteria of a ‘goods‘ – a thing of value which could be sold or purchased. Imaginary goods could also be sold but they did not meet all of his criteria for ‘goods‘ because their value was more transient – in the imagination of the buyer and/or seller rather than clearly apparent to any normal consumer of goods. (Principles of Economics, by Carl Menger, a translation in English)

As I’ve been working on devising ways to make pomegranate peel edible I’ve been thinking about the idea of a market or demand for a good versus the actual value of the good. You can’t sell something of value if no one considers it valuable even if it fits the criteria of being ‘goods‘ – fulfilling human needs; while it recently was brought to my attention, a refresher course having grown up in era of ‘Pet Rocks,” that some people will pay for anything if it is popular – if other people are bidding on the item too. I was astonished as a child that anyone would pay real money for a rock in a box just because it was called a ‘Pet Rock‘ – just go outside, find a rock, stick it in a box – there you go, your very own ‘pet rock’ captured from its wilderness and tamed for your own enjoyment. The current trend that was brought to my attention is less solid but requires an imagination – virtual cats, bred to have unique characteristics, the bidding is based on the uniqueness of the characteristics (investopedia.com) – my thought, too much time or too much money, and too little space for a real pet cat.

People need love and affection as it promotes oxytocin and dopamine which are hormones that promote positive feelings.

For those with limited room in their lives for an expensive virtual cat, consider going outside and looking for a wild rock to tame instead.

Bringing this back around to the New Year’s Day topic of good luck black-eyed peas and the following day’s topic of superstition – Carl Menger includes in his examples of imaginary goods items that might be considered good luck charms and also medications that aren’t effective.

Pomegranate peel might be effective but until there is proof that it is effective there might not be a market of consumers willing to pay for it let alone even try it. So Master Chef Challenge – Pomegranate Peel -> make it appetizing and if people also feel good after eating it then they will return for seconds -> thus creating a market that hadn’t previously been known.

Carl Menger’s four criteria for what makes something a consumer ‘good’:

“If a thing is to become a good, or in other words, if it is to
acquire goods-character, all four of the following prerequisites
must be simultaneously present:

A human need.
Such properties as render the thing capable of being brought
into a causal connection with the satisfaction of this need.
Human knowledge of this causal connection.
Command of the thing sufficient to direct it to the satisfaction
of the need.” page 52 (Principles of Economics, by Carl Menger, a translation in English)

According to his theory something can lose its value as a consumer good if it stops fulfilling any one of those four criteria, to paraphrase – if we 1: stop needing it because the problem it solved no longer exists, 2: the thing no longer works to solve the original problem 3: we forget that the thing is useful for fulfilling the need, 4: the thing is no longer something humans have access to (the WiFi goes out and the virtual cat breeding stops functioning) :

“Hence a thing loses its goods-character: (1) if, owing to a
change in human needs, the particular needs disappear that the thing is capable of satisfying, (2) whenever the capacity of the
thing to be placed in a causal connection with the satisfaction of
human needs is lost as the result of a change in its own properties,
(3) if knowledge of the causal connection between the thing and
the satisfaction of human needs disappears, or (4) if men lose
command of it so completely that they can no longer apply it
directly to the satisfaction of their needs and have no means of
reestablishing their power to do so.” -pages 52-53 (Principles of Economics, by Carl Menger, a translation in English)

So for those who may have forgotten (reason #3), – caring for living people or pets can help one’s own health through increased oxytocin, dopamine and reduced oxidative stress. If owning a real pet is not possible due to housing issues visiting a local Humane Society type agency and volunteering to help care for the shelter animals is generally possible and appreciated. If money isn’t a problem hiring a human for a service that involves touch such as a manicure is helping others by providing money for jobs and providing oxidative stress reducing touch from the hands-on service. If owning a real pet or hiring human hands-on service isn’t possible than oxytocin, dopamine and possibly even reduction in oxidative stress may be provided by a caring relationship with a houseplant that cleans the air of toxins (ferns and other types), or by enjoying looking at art objects that have to do with nature or possible the touch of a smooth natural object such as a rock or crystal or wooden object.

While my search of oxidative stress and art didn’t turn up the link I was looking for it did find a review of research on male infertility, oxidative stress, antioxidants (vitamin E, C and CoQ10) and ART, assisted reproductive techniques, while it doesn’t mention iodine it’s worth saving for reference and smoking is mentioned as risk: http://ccf.org/reproductiveresearchcenter/docs/agradoc261.pdf

Smoking increases intake of formaldehyde as well as other toxins. There are also other common sources of formaldehyde in modern living environments. Tips for reducing risk of formaldehyde exposure and links for the houseplants that help detoxify indoor air from formaldehyde and other common volatile chemicals are included in an older post, Formaldehyde (volatile – chemicals that might be easily released from plastics or carpets into the air – ie “new car smell”).

The topic on nature and art and oxidative stress is discussed with links in the section Art – Food for the Eyes on another website, effectivecare.info, 10. food Helps Too.

Returning to the Master Chef Challenge – Pomegranate Peel, – it is helping my mood and health more consistently than the 1/2 cup of pomegranate seeds did but it is quite acidic. I’ve taken to using a couple spoonfuls in my bean soup instead of the lime juice or apple cider vinegar that I had been adding as a digestive aid. I’ve also tried it on salads in place of lime juice.

As a beverage I occasionally have the original blend of approximately 3 ounces of the pomegranate extract/soup stock with about 3 ounces of water and 1 ounce of cherry juice with four pinches of Baking Soda (sodium bicarbonate) to make it less acidic. Sugar is inflammatory in itself so I’v stopped using much of it. After the review of the blueberry/rhubarb jam recipe I bought some blueberries and will try a combination of the pomegranate extract with the less acidic fruit. Cherry juice is also acidic. Blueberry juice concentrate is available in specialty stores but I wasn’t at one. The Baking Soda may be too much sodium or something in the pomegranate extract or the level of acidity it adds to the diet may have a diuretic effect like coffee – so like many things in life – it’s not perfect. But being sick isn’t either.

When you start thinking about food as fuel and as your body’s natural medicine cabinet then taste is something that can be acquired and adapted to suit the needs of health – but first the mind has to overpower the habit of “I always eat what my family ate, or what I got used to at college, or whatever my friends are eating.” Social settings and food are very strongly linked and it can be viewed as rude to refuse an offer of food that is being offered – sometimes life isn’t perfect either.

Good luck and best wishes all you Master Chefs out in virtual reader land – I know you can take on whatever culinary challenges you choose.

If at the beginning of 2017 someone predicted that I would successfully be using pomegranate peel, baker’s cocoa, cardamom, and leafy green herbs and vegetables instead of medical marijuana for my autoimmune health condition I might have thought they were imagining things – but Carl Menger was right we have to know the causal connection between a good and a problem it might solve before we go to the effort to purchase, prepare, and use the good for solving that problem/need (health care improvement in my case). pages 51-58, (Principles of Economics, by Carl Menger, a translation in English).

A tastes better than it looks salad – Blueberry Pomegranate Avocado Quinoa Salad.

Bring two and a half cups of water to a boil and add one cup quinoa (or amaranth or cracked wheat for a more traditional tabouli like salad). Cook for twenty minutes at a simmer. Stir occasionally to keep it from sticking to the saucepan. Once the water is fully absorbed remove the pan from the heat and add about (all of the following ingredients are estimates except for the avocado- this is a first try) one tablespoon coconut oil and stir into the hot cooked cereal. Add about one cup of frozen or fresh blueberries, 1/2 cup frozen or fresh pomegranate seeds, 1/4 cup pomegranate peel extract, one chopped ripe avocado, one tablespoon dried tarragon and one tablespoon dried basil (or more if fresh is available), and 1/4 cup chopped walnuts. Stir the mixture thoroughly. The cereal will turn purplish color from the blueberries. Serve a cup or so of the mixture over a plate of chopped salad greens and top with a pretty 1/8th cup of fresh or frozen pomegranate seeds.

I always add salt to taste at the table. We taste only the salt on the surface of food, not what has been cooked into a food or stirred into a mixture as much.

The flavors and textures work well together, sweet and tanginess from the fruit, creaminess from the avocado, quinoa and coconut oil. Tarragon adds flavor, the basil is milder and wasn’t noticeable in the amount I added here. Tarragon has a slightly minty flavor. The walnut is a stronger flavor and the crunch and flavor balance with the flavor of the blueberries and crunch of the pomegranate seeds. This was a success flavor and texture-wise no matter what it looks like and it would be nutritionally balanced with protein, essential fats and carbohydrates and plenty of fiber and trace nutrients and antioxidants. Walnuts and blueberries have both been found effective for cardiovascular health and male health issues.

Blueberry Pomegranate Avocado Quinoa Salad

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

December 28, 2017

Pomegranate peel may be the best part – medicinally

I’ve been experimenting with making pomegranate peel extract and it may be the best part medicinally but is quite acidic and quite bitter. Mary Poppins sang that a spoonful of sugar helped the medicine go down and she is on to something. Medicinal herbs may be the bitter ones. Sugar does help with the taste, but excess amounts of it can help worsen inflammation, so just a spoonful is important. Diluting with extra water and adding a concentrated fruit juice also helped with flavor.

I’m taking notes but am still in the testing phase so this is a summary – yes it seems possible to make an extract from the peel and inner membrane part of the pomegranate. The taste is something that a sick person would tolerate because feeling better is worth a lot including drinking something not very good as quickly as possible. However the healthy person is still likely to prefer the pomegranate juice or juicy crunch of the seeds. If there are seasonal issues one simple experiment worked well – the juicy seeds freeze quite nicely so making a large batch of peel and membrane extract could include simply freezing the seeds for later use in salads or as a sweet and tangy treat. The juice is also tart but the peel extract I made was more acidic than coffee I added baking soda to make it less acidic and easier for the digestive system to tolerate.

The extract did help more of my symptoms than the seeds do. I’ve had early signs of finger numbness, possibly Raynaud’s Disease/Syndrome, which doesn’t really have any treatments. The extract helped restore feeling to my fingers but it was temporary, just that day so the larger quantity of the treatment mentioned in the last post on this topic which used 1 – 10 grams/kilogram for 8 weeks for hepatocellular carcinoma might be best spread out through the day for someone with a more severe illness. Half a cup per day for someone less ill and a half a cup every three to four hours throughout the hours spent awake for someone who is more severely ill might be what helps symptoms. If every cell of the body needs the substances, every hour of the twenty-four, then one dose one time per day might leave the body under-treated for most of the 24 hours and only relieve symptoms for a few hours.

Raynaud’s Syndrome/Disease is referred to by both names. It was mentioned in the search engine results but the article is only available as an Abstract which doesn’t mention any specific conditions: (1). The condition is discussed in an full text available article on oxidative stress and Nrf2. It mentions green tea extracts and Gingko biloba as possibly helping reduce oxidative stress: Review Article: Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis, (2).

Gingko biloba is also mentioned along with Raynaud’s Disease in this article. A standard dosage is mentioned as being used once or twice per day: “The standard clinical dose of EGb 761 is 120 mg (~1.7 mg/kg) once or twice daily;” Egb is a standardized formulation that contains a certain amount of the active phytonutrients of the Gingko biloba herb which are called gingkolides. It is a traditional herb that was used in cooking and as a medicine in Chinese and Japanese history for conditions such as asthma or as a cough medicine. In the discussion of Future Directions for research the authors suggest more study of dosing as the amount used in preclinical trials was significantly more than used in many clinical trials, “(100 mg/kg compared to <2 mg/kg, respectively),” although some used a larger dose, (300 mg daily). (3).

I do take a capsule of Gingko biloba daily but not the Egb formulation. The dose I have been using is 60 mg standardized to include “24% Gingko Flavoglycosides = 14.4 mg and 6% Terpene Lactones = 3.6 mg” – which suggests it is a fairly low dose compared to some of the research studies that used 100-300 mg of the Egb formulation. (3)The Egb formulation also includes flavanoids which include one that has been found to help increase Nrf2:

“Beyond oxidant scavenging, the flavonoid isorhamnetin was able to upregulate antioxidant enzymes through Nrf2 activation.^63″(3).

Take home point – clinical trials are a lot of work and accurate dosing, both amount used, concentration of the active phytonutrients, and frequency the dose is used throughout the day, and how large the patient is, are all important factors for effectiveness of the herbal preparation at relieving symptoms of a disease or preventing chronic illness.

DaigoSumi, AikoManji, YasuhiroShinkai, TakashiToyama, YoshitoKumagai., Activation of the Nrf2 pathway, but decreased γ-glutamylcysteine synthetase heavy subunit chain levels and caspase-3-dependent apoptosis during exposure of primary mouse hepatocytes to diphenylarsinic acid., Toxicology and Applied Pharmacology, Vol. 223, Issue 3, 15 September 2007, Pages 218-224. http://www.sciencedirect.com/science/article/pii/S0041008X07002633 (1)
Bogna Grygiel-Górniak and Mariusz Puszczewicz,Review Article: Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis, Mediators of Inflammation, vol 2014 (2014), Article ID 389582, 11 pages. https://www.hindawi.com/journals/mi/2014/389582/. (2)
Kevin M. Nash and Zahoor A. Shah., Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders., Integr Med Insights. 2015; 10: 1–9.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640423/ (3)

December 24, 2017December 24, 2017

It is not a coincidence that my phospholipid rich diet overlaps with the Nrf2 promoting foods

The punchline – phospholipids are the building block of cannabinoids which are also a phytonutrient that causes an increase in production of Nrf2. (1, 3) The most concentrated source of cannabinoids or phospholipids is found in medical marijuana or the non-euphoric CBD oil which is more likely to be available legally. However there are other legal sources of phospholipids and cannabinoids. The phytonutrients are also found in cocoa beans/baking cocoa/dark chocolate (processing reduces the concentration and availability of the ‘bitter’ tasting nutrients in more processed milk chocolate and chocolate syrup.) Phospholipids add a slight bitter taste to foods which I’ve always been able to taste and tend to prefer. A genetic screening did find that I have a double/ both sets of genes/ difference in my ability to make any chemical with phosphorus – the phospho- part of phospholipids which are important in many chemicals in the body not just cannabinoids. (4 – an open access textbook on phosphorylation)

For example the original Lemonhead TM candies have more flavor to me than the more recent version of lemon flavored Chewy Lemonhead, (lemonhead.com). Bitterness is something we have a specialized set of tastebuds to detect. Our tastebuds have a few specific types and there are some that detect sweet, salty, sour, bitter, and some for Umami (fermented protein/free amino acid/a hint of soy sauce like flavor). Recently reseachers have suggested a set detect starch but sweet is also a starch so it might be similar to the sweet detecting tastebuds. The article explains that the difference between simple sugars and complex, longer chain carbohydrates called polysaccharides, can be detected suggesting there are two types of carbohydrate sensing tastebuds. (2)

Our sense of smell adds a lot more differences to our enjoyment of foods and beverages. Terpenes are particularly good smelling and other phenolic compounds also add aroma. Cinnamon and vanilla, basil, oregano and lemon are all sources of phenolic compounds or terpenes. These were discussed in more detail in the recent post on Nrf2 and diet tips for promoting Nrf2. It is a protein that causes genes that make important antioxidants to become active so it helps protect us against damage from oxidative stress which can be caused by health factors or by real world worries whether an upsetting conversation or bad traffic.

Pomegranate seeds (not the juice) and pumpkin seed kernels are also good sources of phospholipids. The spice cardamom powder is also a good source. See the section The DASH Diet and Pumpkin Seeds on the home page of my other website: effectivecare.info. A salad recipe and more information about genetics and cannabinoids are also available on that site or in the post Is it Starvation or Addiction?

Pomegranate extract has been studied in animal based research to examine in more detail how it helps hypertensive blood pressure problems and reduce oxidative stress. The mechanism was found to involve increasing Nrf2. The formation of mitochondria increased, and their function improved. Before treatment the hypertensive animals had fewer of the specialized proteins that are involved in production of mitochondria. Mitochondria are the cellular organelles primarily responsible for turning blood sugar/glucose into usable energy. (5)

This study uses a pomegranate extract that incorporates the peel, seeds and juice as all contain the bioactive phytonutrient, punicalagin, thought to be most helpful for anti-inflammatory, anti-tumor and anti-diabetic effects. The animals who received the extract were found to have better blood pressure, reduced heart hypertrophy ( a sign of worse heart health) and a lower heart rate. Neuronal/nerve cell activity and oxidative stress markers were decreased in the experimental treatment group compared to the control group which received a saline solution and no pomegranate extract. Angiotensin converting enzyme which is involved in blood pressure control was lower in the experimental group that received pomegranate extract and may be the mechanism for the lower blood pressure. Pro-inflammatory cytokines were reduced in the experimental group after treatment, an indication that hypertensive inflammation was reduced. The pomegranate extract treatment led to increased levels of phosphorylated AMPK which then leads to an increase in Nrf2 and its resulting increases in antioxidant proteins which protect against injury and inflammation from oxidative stress chemicals. (5)

Pomegranate is referred to as an ancient fruit in a research study on its benefits against hepatocellular carcinoma. Spoiler alert – it was found beneficial. (6)

“PE (Pomegranate Extract) treatment (1 or 10 g/kg), started 4 weeks prior to the DENA challenge and continued for 18 weeks thereafter, showed striking chemopreventive activity demonstrated by reduced incidence, number, multiplicity, size and volume of hepatic nodules, precursors of HCC (Hepatocellular Carcinoma).” (6)

One to ten grams per kilogram (1 to 10 g/kg) (6) gives us a quantity but that is of the extract which is made with the juice, seeds and peel. The inner peel is whitish in color while the outer peel is vibrantly colored similarly to the juice. An average adult weighs somewhere around 70 kg (68 kg ~ 150 pounds) so the animal study used an equivalent of 70 to 700 grams of pomegranate extract. Five grams is about a teaspoon so 70 grams would be slightly less than 5 Tablespoons or about 1/4-1/3 cup which is roughly a half a pomegranate worth of seeds with the juice and would be a reasonable serving size. Ten times that would be more than a typical serving at approximately two and a half to three and a third cups of pomegranate extract per day, for 22 weeks (6) – but if you have Hepatocellular Carcinoma that might sound good compared to other chemotherapy treatments.

My health and anxiety seems to be improved with a half a pomegranate worth of the seeds per day, or half in the morning and half in the evening when anxiety is worse. I have not tried using any part of the peel or interior whitish colored membranes so I don’t know what how edible they would taste. Pumpkin seed kernels are a higher fat food and the serving size is about 2 to 4 tablespoons, 1/8 to 1/4 cup as a snack my themselves or sprinkled on a salad. I prefer to have some of both foods every day. As well as other dark green leafy vegetables and herbs, beans, rice, nuts and other seeds, and ground lemon powder and/or lime or lemon juice. One healthy food alone isn’t enough to improve my health and mood on it’s own however the half a pomegranate can improve my mood when I’m having a worse anxiety moment. Pumpkin seed kernels are a higher fat and protein substance and don’t seem to have the quick acting mood lifting effect but I notice when I run out of them and don’t have any for a few days.

Regarding the “ancient fruit” reference in (6), yes pomegranate is mentioned in the Bible, Old Testament; 1 Samuel 14.2, “Saul was staying in the outskirts of Gibeah under the pomegranate tree…” and Old Testament; Haggai 2.19: “Is the seed yet in the barn? Do the vine, the fig tree, the pomegranate, and the olive tree still yield nothing? From this day on I will bless you.” (7)

Menu tips to be continued later, Happy holidays!

Li X., Han D., Tian Z., Gao B., Fan M., Li C., Li X., Wang Y., Ma S., Cao F.,
Activation of Cannabinoid Receptor Type II by AM1241 Ameliorates Myocardial Fibrosis via Nrf2-Mediated Inhibition of TGF-β1/Smad3 Pathway in Myocardial Infarction Mice., Cell Physiol Biochem 2016;39:1521-1536, https://www.karger.com/Article/FullText/447855 (1)
Chase Purdy, The human tongue has a sixth sense and its a taste bud that loves carbs. Quartz, qz.com, Sept. 8, 2016, https://qz.com/776857/the-human-tongue-has-a-sixth-sense-and-its-a-taste-bud-that-loves-carbs/ (2)
Wang Y, Ma S, Wang Q, Hu W, Wang D, Li X, Su T, Qin X, Zhang X, Ma K, Chen J, Xiong L, Cao F: Effects of cannabinoid receptor type 2 on endogenous myocardial regeneration by activating cardiac progenitor cells in mouse infarcted heart. Sci China Life sci 2014;57:201-208. https://www.ncbi.nlm.nih.gov/pubmed/24430557 (3)
Claude Prigent, Editor, Protein Phosphorylation, Publisher: InTech, Chapters published November 29, 2017 under CC BY 3.0 license InTechOpen.com, https://www.intechopen.com/books/protein-phosphorylation (4)
Wenyan Sun, Chunhong Yan, Bess Frost, Xin Wang, Chen Hou, Mengqi Zeng, Hongli Gao, Yuming Kang,and Jiankang Liu,
Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats., Sci Rep. 2016; 6: 34246. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054377/ (5)
Anupam Bishayee, Deepak Bhatia, Roslin J. Thoppil, Altaf S. Darvesh, Eviatar Nevo, and Ephraim P. Lansky., Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms., Carcinogenesis. 2011 Jun; 32(6): 888–896. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314278/ (6)
Holy Bible, Revised Standard Version, Containing the Ole and New Testaments, Thomas Nelson & Sons, New York, 1952, 1 Samuel 14.2, page 297, Haggai 2.19, page 984 https://www.amazon.com/1952-Revised-Standard-Version-Bible/dp/B000U2L3E0 (7)