Tag: oxidative stress

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G3.6: Antihistamines may help if there is a genetic tendency to overproduce histamine.

Genetic differences in more than 70 genes have been associated with increased itchiness, see summary at the end of this section. (G3.24) Calcium and serotonin levels may be involved in increased itch or arthritis pain signals being sent or perceived. (G3.25) Scratching an itch is considered rude and a chronic itch is often considered funny however it isn’t fun.

Some background information:

Too much or too little calcium and magnesium can affect pain, itching, and mood. The minerals are both electrically active, and provide energy for ion channels which control the transport of messenger chemicals like serotonin across cell membranes – such as nerve cell membranes which might feel like a sensation of itchiness or pain.     

Excess serotonin may be involved, (G3.26, G3.27), and scratching an itch can make the urge to scratch more intense, even worse afterwards, even though there may be a temporary feeling of relief while scratching. (G3.28) Adequate magnesium is essential for reducing pain in arthritis or at least may help reduce pain levels. (G3.27) An antihistamine may help for some types of itching related to genetic conditions. (G3.29)

Excess dopamine levels can also be a cause of an overwhelming urge to scratch – see “grooming behavior” in section 7. When to Report?. The solution there is to figure out why dopamine levels are that elevated. Elevated dopamine can be a symptom of hyperthyroidism but it can also be associated with other conditions.

  • An Itch You Just Can’t Scratch; NIH-funded study identifies proteins that may cause chronic itch. Summary points: The HTR7 gene was found most closely associated with chronic itch in an animal based study, however over 70 genes were found to be more expressed, more active in lab animals with chronic itch. The gene expression of the HTR7 gene was most active in the mice with the worst symptoms of scratching compared to the mice with the least sensitivity. The activity of the TRP1 receptor was also increased in animals with more symptoms. (G.24)
  • Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice. Summary points: The TRPA1 receptor is directly activated by calcium levels inside of the cell, and a variety of toxins or “noxious” (irritating) substances that are produced as a normal part of “oxidative stress” otherwise known as “inflammation” including, “4-hydroxy-2-nonenal, hydrogen peroxide, hypochloride, hydrogen sulphide, 15-delta prostaglandin J2 [25–28].” and irritants from the environment or diet can also activate the TRPA1 receptor, *1.“mustard oil (allyl isothiocyanate: AITC) [29], *2. cinnamaldehyde [30, 31], *3. allicin [32, 33] and *4. formalin [34]…”. (G3.25) Serotonin and other “Inflammatory mediators, such as bradykinin…[19, 35]” (G3.25) can make the receptors more sensitive which can lead to increased responsiveness of nerve endings – more pain (G3.25) or itch. (G3.24) *See the next section for more information about the chemicals in bold font and where they may be found in the diet or environment.

*People with overactive TRPA1 channels may be sensitive to:

  1. Mustard:  “mustard oil”
  2. Cinnamon:  “cinnamaldehyde'” (G3.43) );
  3. Onion or Garlic: “allicin,” (G3.41)
  4. Formaldehyde: “formalin,” chemically the two are very similar: (G3.42) and formaldehyde is found in the environmental and as a metabolite of some alternative sweeteners and other dietary sources. (G3.56) Environmental sources include which would include first and second hand smoke, poorly ventilated air or smog, especially when there is brand new flooring or other new plastic or vinyl  material in the living area, it  can release volatile chemicals including formaldehyde at levels that can make a sensitive person feel ill. Metabolites of the breakdown of the alternative sweetener aspartame and Neotame include menthol and formaldehyde. (G3.44) Older packages of fruit juice also may contain increasing amounts of formaldehyde as the product ages, more of the chemical is produced from other chemicals.

Magnesium, Opioids, and Neuropathic Pain.

This list and this section got much longer actually, and eventually led me back to a topic I’ve written about in 2011, and which is one of the underlying causes of overactive TRP channels. Fortunately it also has a simple solution, (G3.101), but – unfortunately – it is so simple a solution that it isn’t profitable – unfortunately for individual patient’s health and quality of life and unfortunately for the economic health of individuals and nations and businesses who are being overcharged by the medical industry for healthcare that isn’t always effective and sometimes causes harm.

It is so effective a solution for improving mood and pain and muscle cramp type symptoms that I’ve been sharing the information online since at least 2011 and the article I shared was research from 2009, (G3.101), – so the clock is ticking on how soon the evidence based medical research will reach the individual patient who is in pain. The racers at the starting line are the physicians and nurse practitioners and other health professionals who make recommendations for opioid medications in an attempt to block pain instead of trying to find and resolve the cause of the pain.

What is a nerve signal? “Pain” or “no pain”? or “on” and “off”?
Pain, however, should not just be blocked without trying to understand the cause. It is a message from the body desperately asking for help but it is not always a clear message. Pain in one area of the body may have to do with an issue in another area of the body. Instead of blocking the pain signals we need to listen to them more carefully and try to figure out what the pain signals mean and how to resolve the underlying cause of the pain. Something might be missing and need to be added back into the diet or something might be happening in excess either in the diet or lifestyle habits and need to be stopped or moderated.

Nerve signals are not specific to send the brain a message of “pain” that exclusively means “pain;” a nerve signal is more of an “on” or “off” and might indicate a variety of extremes: too hot or too cold, or too rough or too light (ticklish), or too hot peppery, (capsaicin, (G3.100), more on that later), or too mustard oily. The nerve signal is simply telling the brain that “something” happened – figure it out captain of the ship – and fix it – such as remembering to wear gardening gloves before handling wild mustard weeds, especially if you have diabetic hypersensitivity.

The TRP channels are the bridge between the world and the nerve signal. There are many types and they can respond to specific temperatures, so some might activate when it is very cold and some might activate when it is very hot. Some might react to the hot pepper and some might react to the mustard oil. They would all tell the same nerve – “something” extreme happened.

Mustard oil can cause an extremely itchy reaction. It is used to induce “hypersensitivity” in lab animals to study the condition in relation to diabetic hypersensitivity. This will be discussed in the next section in more detail. (G3.96) Wearing gloves may be advisable when pulling a patch of wild mustard if you tend to have sensitive skin or allergic reactions.  (p124, G3.97)

Antihistamines taken daily can be helpful if excess histidine is a problem.

Antihistamines taken as a daily precaution may be helpful for people with overly sensitive skin if the sensitivity is related to a tendency to overproduce histidine. (G3.29) If that is an issue, then taking an antihistamine medication daily may also help for some types of chronic pain as well, more will be included in the next section. Acupuncture is a traditional therapy that may help reduce the overactivity of TRPV channels and reduce the production of the inflammatory peptide Substance P and other cytokines. Acupuncture can affect both the opioid and the cannabinoid receptors – but without needing the prescription or having to experience the side effects! (G3.104)

See a healthcare provider for medical advice, diagnosis or treatment.

  • Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

The Academy of Nutrition and Dietetics has a service for locating a nutrition counselor near you at the website eatright.org: (eatright.org/find-an-expert)

References:

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G3.4: Social contact would help protect against oxidative stress.

People and other species are social creatures whose survival may have been dependent on being part of a group rather than being isolated. Loneliness has been associated with increased inflammation and a reduced resistance to infection by viral diseases. Genetic changes have been found to occur in isolated individuals that lead to the increased inflammatory response in comparison to individuals who have more social support. Genes can be temporarily turned on or off depending on the environment.

Our instincts have developed to trust that being part of a group increases our chance of survival. Having a role that fulfills a valued purpose for the group is associated with an increased sense of happiness. Read more: A Better Kind of Happiness, by Will Storr, (G3.9).

Fitting into groups well can require social skills that need to be nurtured from birth. Infants learn body language at an early age by interacting with a parent who responds to the baby’s cues. If the baby smiles the mother smiles back and the baby learns to smile more readily. If the baby has a mother that doesn’t notice body language though, then the infant may stop smiling as often.

Infants and children depend on their caregivers for everything and try to please with their smiles, eye contact, or baby coos. If the infant isn’t receiving eye contact in return however they may stop trying or are scolded they may learn to look away and to avoid eye contact.

Children ideally need emotional support in order to develop trust in themselves and in others. Parents who have limited skills in understanding and accepting their own emotions may not be able to teach their children what they don’t understand themselves. Children who have some role model in their lives who understands emotional skills may cope better than children who don’t.

The topic is discussed in more detail in the book Adult Children of Emotionally Immature Parents: How to Heal from Distant, Rejecting, or Self-Involved Parents, by Lindsay C. Gibson, PsyD, (New Harbinger Pub., Inc., 2015, Oakland, CA) (G3.10) (This book is not a twelve step book and is not affiliated with the Adult Children of Alcoholic or Dysfunctional Parents twelve step group.) On page eight the author discusses the importance of emotional connection for humans and other mammals for responding less negatively to stress. Stephen Porges published work in 2011 suggesting that mammals evolved a way in which we can get additional soothing during fear situations when we are in touch physically or possibly even mentally – thinking about them during times of need. It involves vagus nerve pathways that can be inhibited to reduce the fight, flight, or freeze stress reaction. (G3.10)

So a sense of connection to others can help reduce the negative inflammatory effects of the stress response. Some stress can be healthy to help get us moving to meet whatever challenge has occurred. Stress may become more overwhelming however if the person is isolated or never learned social skills or developed enough trust in others to ask for help or seek out help.

Children in situations with emotionally immature caregivers may learn that people around them can’t be trusted or that trying doesn’t lead to success so why bother trying – they can learn a sense of helplessness and hopelessness and not even try to seek help because they are unfamiliar with finding strength or support from others.

In the book Adult Children of Emotionally Immature Parents: How to Heal from Distant, Rejecting, or Self-Involved Parents, by Lindsay C. Gibson (G3.10) four different types of emotionally immature caregivers are described and how growing up with them might affect children. Solutions are also provided in the form of techniques for how, as an adult, a person might overcome the lessons they learned as a child once they discover that emotions aren’t dangerous things to never be discussed or worse –  that one might be punished for exhibiting them.

Some emotionally immature people may feel threatened by strong emotions and may react negatively to children who are simply being children. The child in that situation learns to not trust themselves and may not learn that emotions are normal rather than upsetting or frightening.

Severe childhood trauma can lead to changes in the brain that cause ongoing symptoms of Post Traumatic Stress Disorder (PTSD). A new strategy for treating PTSD has been developed which involves electrical stimulation of the vagus nerve called Vagal Nerve Stimulation (VNS).  

The excerpt summary from the book Adult Children of Emotionally Immature Parents (G3.10) regarding the research by Stephen Porges suggests that the vagal nerve is the nerve pathway that naturally is stimulated when social contact is sought by mammals who are enduring a stressful situation. (G3.11) (G3.12)

Whether you are a parent or a teen or an adult learning more about emotional maturity and immaturity can help understand your own emotions and others. Whatever we grow up with will seem normal to us and as adults we tend to seek out similar relationships to those we were familiar with as children – but sometimes what seems normal to some people isn’t normal for everyone else and there is no need to continue living in abusive situations just because it seemed like a normal part of life as a child.

Lack of emotional skills may increase the risk of acting inappropriately when under severe stress. People need the support of people to help reduce negative effects of stress and increase a sense of connection and purpose. People need to learn emotional skills from people who have emotional skills  – or sometimes from a book, Adult Children of Emotionally Immature Parents: How to Heal from Distant, Rejecting, or Self-Involved Parents, by Lindsay C. Gibson: (G3.10)

  • Attachment Theory and parenting styles are discussed in section 8. Trust is learned early.

The descriptions in this section suggest the inconsistent parenting of the Disorganized style or a parent that switches between Avoidant and Anxious-Resistant styles. A more trusting  Secure style can be achieved with the help of Cognitive Therapy techniques and practice; but it is a lot of work to change core values, or more realistically – attempt to modify slightly, core values that remain from early childhood. Art Therapy or EMDR therapy can help access nonverbal feelings and events that may have occurred during the preverbal years of childhood. Dialectical Behavior Therapy can help when there are cognitive and physical issues underlying mood symptoms.

  • Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
  • The Academy of Nutrition and Dietetics has a service for locating a nutrition counselor near you at the website eatright.org: (eatright.org/find-an-expert)

References:

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Effectivecare.info, website launch

The series on oxidative stress is available in the full length version now. I still plan to add the individual sections to the blog, as it has a search feature that the new website does not have.

The series on oxidative stress is skipping ahead of the main text of the new website. This is the page link which I’ve been posting the first couple sections of on this site, this site is also embedded in the new site, so it can be accessed there in case finding something is difficult one way, why not post it in afew formats?

Read more:

  1. G3. Relaxation & Stress, (G3)
  2. the series continues in G4. Autoimmune Disease & Vitamin D, (G4),
  3. G5. Pre-eclampsia & TRP Channels, (G5)
  4. and G7. Fear & our Inner Child. (G7)
  • Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. 
  • The Academy of Nutrition and Dietetics has a service for locating a nutrition counselor near you at the website eatright.org: (eatright.org/find-an-expert).
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G3.3: Negative stress can trigger the “fight-flight” response – Who’s at Risk?

Stressful times can make fear and anxiety more likely as our body’s instincts expect to either run from danger or to freeze in position, possibly in the hopes of not being noticed by a predator.

Who’s more at risk to experience negative stress?

Who is more at risk to experience a challenge with a negative fight, flight, or freeze stress response? (G.10)  Instead of having their body or mind perceive a stressor as a positive challenge and an exciting reason to get up each morning ready to say “Carpe diem”?   

Who is more at risk to experience stress as a negative stress response instead of seeing it as a positive challenge and reason to get up and get busy?

  • Answer: many groups are more at risk for having their bodies respond to an event with more of a negative stress response than the average person.     

People more vulnerable to the negative health effects of stress include:

  • older adults;
  • mothers and especially working mothers;
  • less educated individuals;
  • divorced or widowed individuals;
  • people with financial concerns or lack of health insurance;
  • isolated or lonely people;
  • people who are targets of racial or sexual discrimination;
  • people who live in cities,
  • and people with a history of childhood trauma can be more risk to feeling stress.
  • Summarized from “Stress“: (G3.5), University of Maryland Medical Center.

Antioxidant foods can help protect against negative effects from stress.

Eating antioxidant rich foods can help protect the body from negative effects that can occur due the waste chemicals produced during normal metabolism and increased during situations that cause more oxidative stress from  either emotional or physical reasons. Angry and tense due to having to hold in your temper at work, or angry and tense because the traffic was so physically dangerous to navigate simply to get to work in the first place; – both can increase the amount of oxidative stress occurring throughout the body.

Social contact with caring people can also help the body physically detoxify negative chemicals produced during stress or produce less of them in the first place, that will be discussed more in the next post. (G3.10)

The stress response produces chemicals which can cause other inflammatory reactions throughout the body. Having extra antioxidant rich fruits and vegetables and assuring adequate omega 3 fatty acids was shown to help reduce inflammation in autoimmune Celiac sprue. (G3.6)

Dark chocolate has also been shown to be beneficial antioxidant source. Forty grams (1.3 ounces approximately) per day of chocolate was found beneficial with a college student population. (G3.7) That is quite a bit of chocolate for someone with limited room for the empty calories from sugar. Sesame seeds would provide antioxidants with no added sugar.

Eating sesame seeds as part of the daily diet has been shown in sports research to help reduce oxidative stress. The trial subjects ate 2 tablespoons per day of the seeds. See: Effects of Sesame (Sesamum indicum L.) Supplementation on Creatine Kinase, Lactate Dehydrogenase, Oxidative Stress Markers, and Aerobic Capacity in Semi-Professional Soccer Players. (G3.8)

Using tahini in the diet regularly would have similar health benefits. Raw oil or seed butter products may have the most antioxidant content. Look for the phrase “unroasted” on a seed or nut butter product or “cold pressed” on the label of an oil or coconut oil product. Tahini is a sesame paste similar to peanut butter except it has different flavor. The flavor is stronger and to my taste does not go well with sweet jams or jellies like peanut butter or sunflower seed butter. I have found daily use of tahini to be more beneficial to my health then sunflower butter as a substitute for peanut butter – which I have to avoid. I have many dietary restrictions because I feel better without the foods, due to intestinal sensitivities and the autoimmune inflammatory reactions that can occur when I have even very small amounts of some things.

My easy answer to fueling my body so I can get back to what I like doing – reading and writing – is simply tahini spread on rice cakes. I’m used to it now and eat it plain but when I first started eating it I would drizzle a small amount of blackstrap molasses on as a sweetener with a stronger flavor and a good supply of iron and trace nutrients. Or more often I would sprinkle ginger powder on for a zingy accent that provides pain killing anti-inflammatory chemicals. Later in this section on oxidative stress TRP channels will be discussed and their unfortunate sensitivity to many common foods – including ginger. Sadly for my diet and inflammatory condition, I no longer can use ginger due to the intestinal overactivity of TRP channels – presumably, more on that in a later section –  however it may take a while, note the abrupt change in the next footnote number, there is some stuff in between the beginning and the end of the footnote list:

Chocolate and antioxidant foods and herbs found helpful for stress are discussed in more detail with references on a UCLA webpage providing information about integrating Eastern medical philosophies and treatments with Western medical methods. (G3.112)

To provide sustenance for the journey and a way to add chocolate to your diet for anyone who can’t think of any, see my antioxidant rich recipe for chocolate chip cookies. See the third version on this page of recipes and information about gluten free food sensitivity and autoimmune sensitivity for an egg free, butter free, gluten free cookie recipe. It is still a treat with calories and fat, but with fewer ingredients that contain inflammatory chemicals and more ingredients that are very good sources of antioxidants or healthy types of fats: G8.Chocolate Chip Cookies.

Regarding TRP channels – cinnamon is a spice that can activate a type of the membrane gates to allow nerve signals or other actions to occur. The spice has been to help reduce blood glucose levels for patients with diabetes. About one quarter to one half teaspoon per day was found helpful.  (G3.124) A half teaspoon of cinnamon powder is a large amount. Some people enjoy it stirred into a bowl of hot cereal in the morning. It could also be added in smaller amounts to a few cups of hot tea throughout the day, or an evening cup of hot cocoa. Cinnamon is a spice that I avoid due to migraines, it may be causative as a TRPA1 channel agonist. More is included in later sections on TRP channels and the foods that may cause problems for some people such as those with a tendency towards migraines or Irritable Bowel Syndrome or concerns with chronic itch or skin problems such as psoriasis or eczema.

The science regarding cinnamon and blood glucose is complex, some of these terms and chemicals will be discussed in more detail later, this is an introduction to the topic of oxidative stress and TRP channels:

Cinnamaldehyde is a phytonutrient found in cinnamon. It activates ion channels (TRPA1) found in membranes of nerve cells in the tongue and throughout the body. Activating the TRPA1 ion channels causes a release of proteins called peptides from the nerve cells. The nerve cells carry pain sensations and also supply nerve signals to blood vessels. Blood vessel and cardiovascular functions can be beneficially affected by the peptides (including “calcitonin gene-related peptide, (CGRP), and Substance P, (SP)”) and activation of the TRPA1 channels within nerve cells of the gastrointestinal tract can also signal satiety centers in the brain (satiety is the sense of fullness, and hunger signals stop). Cinnamon use by patients with Type 2 diabetes has been found to help decrease blood glucose levels. Release of insulin promoting hormones (“glucose-dependent insulinotropic hormone (GIP) and GLP-1“) by the TRPA1 ion channels may be the reason for the decrease in insulin levels with the use of cinnamon. (page 1118, G3.113) 

How much cinnamon, what type? Cinnamon that included another phytonutrient called linolool was found to be helpful to lower blood glucose levels in an animal-based study at doses of 12.5 or 25 mg/kg of body weight, and more was not better. Doses of 50 mg/kg no longer had the beneficial effect. (G3.124) For a human who weighs 150 pounds/68 kilograms, that might be a serving size of 850-1700 milligrams, which might be roughly ¼ to ½ teaspoon per day – and one teaspoon, 50 mg/kg, would not be more helpful. Many nutrients and other activities in life are good in moderation but may be not helpful or even harmful in larger amounts

See a healthcare provider for medical advice, diagnosis or treatment.

  • Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
  • The Academy of Nutrition and Dietetics has a service for locating a nutrition counselor near you at the website eatright.org: (eatright.org/find-an-expert)

References: