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Spike protein is a toxin. Please stop trusting the experiment.

More research has been revealed over the last year about the odd blood clotting risks found with COVID-19 compared to SARS-1 which had been primarily a respiratory illness. Heart inflammation and shortness of breath has been occurring after receiving the spike mRNA injections in young people. The spike is also hook or velcro like in that it can cause cells to connect together and clump into clots – which may then cause a heart attack or brain stroke. Premature aging of mitochondria may be caused by the spike toxin, affecting cell health throughout the body and vascular system. Endothelial tissue is at risk, more so when vitamin D and C deficiency are present. It may also be reactivating ancient pieces of our own genes which encode precancerous type of protein.

The spike protein itself is too similar to a protein used in the human placenta. The spike protein may also be causing infertility in males ( 11, 12, 13) and females.

Experimenting with infertility in children on a massive scale seems like a big mistake – or a diabolical plan. If it is just a mistake we can stop now can’t we? If it is a profit oriented plan, then do we really want to risk chronic disease and infertility to support more profit for pharmaceutical companies? Is the goal pharmaceutical profit or health?

Watch this video, ON Point with Alex Pierson and guest Dr. Byram Bridle, a professor of viral immunology: New peer reviewed study on COVID-19 vaccines suggests why heart inflammation, blood clots and other dangerous side effects occur. (1)

The spike protein was thought to only interact with ACE2 receptors on cells by the vaccine research teams, (image-8), however it was found in blood plasma and in many organs of the body including the brain and ovaries. (7)

Comment by E Math on article (7) . image by (@HomoSapiensUSA1)

Menstrual symptoms of increased bleeding, even in post menopausal women have occurred in people who received the vaccine – and in people who did not but were around people who had. It has been measured in a small group study to be emitted starting at day one post injection, peaking at day 5, and lasting 15 to 29 days.

This video, Vaccine Shedding and Transfer – Dr. Lee Merritt Explains the COVID Bioweapon, goes into more detail about the spike protein as a bioweapon and gain of function genetic editing research – an interview with Dr. Lee Merritt, (4). “Passive vaccination” has been studied for use in wild animal populations – vaccinate a few and the few animals start producing a pheromone like protein that can pass to other animals and modify their health in some way too (5) – such as to cause infertility and extinction of an unwanted species.

*I will add a few more references about the health issues mentioned in the first paragraphs, but am posting the video link now.

Solutions from our diet – nutrients give our body weapons of defense and offense.

Pomegranate peel (2, 3) may help in addition to vitamin C, D, Bs, magnesium, selenium, iodine, zinc, manganese, boron, other trace minerals and polyphenols/phytonutrients. When we give our body more tools, it has better defensive and offensive abilities.

Just because something is expensive, experimental, promoted with free give-aways and celebrity endorsements, or mandated, doesn’t mean it is safe or effective, and just because something is inexpensive and natural doesn’t mean it is bad for you.

Capitalism has gone down a bad path.

~~

Herd immunity was originally about herds of animals that got sick and developed natural memory cell immunity – if ~ 80% get sick then the rest are protected.

“Herd immunity’ probably takes the prize for being the most misunderstood term of 2020. It is also widely misused to mean the willful culling of vulnerable people.” -Professor Sunetra Gupta, in a Collateral Global mini-lecture and essay on herd immunity (Video: Mini-lecture – Herd Immunity, 6)

There is a common message that adverse reactions from a vaccine are worth not getting sick from the infection – however if the vaccine is providing a toxin that causes similar symptoms as the infection – then are you really better off?

Adverse reactions to the various Covid-19 gene treatments and deaths have been significant and far more numerous than there have been for any other standard vaccine. (18, 19, 20, 21) The gene treatments are not the same as standard vaccines and preliminary animal studies showed extreme danger of death – 100% eventually. The animals tended to get more sick once they were infected after having first received an mRNA gene treatment.

The mRNA or DNA gene treatments may be causing the body’s immune system to ignore the pathogen, as if it was our own protein, rather than a pathogen’s – leading to no immune response to the infection and a severe case leading to death. (17) Flu or cold virus are also coronavirus. There may be increased risk if infected with other strains of coronavirus in addition to the SARS-CoV-2 virus.

The spike protein can inhibit our own cell’s protein production.

The SARS-CoV-2 virus has several proteins that inhibit our own cell’s protein replication so the virus can be replicated instead. The spike protein is one of them.

“…coronavirus NSP1 proteins employ divergent mechanisms to suppress host protein expression (4). SARS-CoV NSP1 binds the small ribosomal subunit at the messenger RNA (mRNA) entry tunnel and inhibits mRNA translation (5, 6). Similarly, ribosome interaction and translation inhibition activity have been reported recently for SARS-CoV-2 NSP1 (7⇓⇓–10). Moreover, SARS-CoV accessory protein ORF7a and structural proteins spike (S) and nucleocapsid (N) proteins have been shown to inhibit protein synthesis (11⇓–13). ” (9)

The bat virus was likely genetically engineered to also have the spike protein but attempt to make it look like a natural mutation, (of SARS 1, MERS, HIV & the bat virus – sounds unlikely to me).

There is new research being published claiming that the spike protein was a gain of function addition to a bat virus that was attempted to be made to look like a natural mutation. Scientists in China who have tried to speak out have disappeared/not been heard from further. (10) Is this true? I don’t know but people are being harmed and pausing at least seems sensible if the goal truly is health.

The spike protein itself can cause lung damage similar to COVID19.

The spike protein itself was found to cause lung damage similar to that seen in COVID19 from the viral infection. A version of the SARS-CoV2 spike protein was added to an otherwise empty viral carrier and symptoms of the illness occurred. (13)

“In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model–proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.” (13)

The spike protein also causes blood vessel damage – endo and epithelial tissue.

  • “These soluble Spike variants may initiate severe side effects when binding to ACE2-expressing endothelial cells in blood vessels. In analogy to the thromboembolic events caused by Spike protein encoded by the SARS-CoV-2 virus, we termed the underlying disease mechanism. In analogy to the thromboembolic events caused by Spike protein encoded by the SARS-CoV-2 virus, we termed the underlying disease mechanism the “Vaccine-Induced Covid-19 Mimicry” syndrome (VIC19M syndrome).”
  • Discussion section
  • “In patients that exhibit a high load of auto-antibodies against PF4, this may cause the observed thrombocytopenia (Fig. 1D, left side).”
  • “These ACE-bound Spike protein variants will become targets of the newly produced [anti-spike] antibodies and will cause an ADCC/CDC-mediated inflammatory reaction involving several immune cells. It may also cause the already described NET reaction of neutrophils which has already been shown to induce thromboembolic events (19–21).”
  • “It also may cause a strong inflammatory reaction by destroying endothelial cells at those sites, explaining the phenomenon of the rarely observed capillary leak syndrome (Clarkson-disease; 22)” (14)

Pomegranate peel catechins help inhibit NET formation. (2) Vitamin C, and D, (15), are also very important for blood vessel membrane formation. (Vitamin C & IL-6 – Covid posts)

“Vit C is essential for innate & adaptive immune system. It also plays an essential role in maintaining the epithelial & endothelial barrier function, maintains vasodilation & reduces the production of pro inflammatory mediators [46]. def Vit C > poor wound healing & scurvy [47].” (16)

Glycine is also used in quantity in the formation of collagen, which means glyphosate residue may be a problem for some patients, or many even. Biofuel made with Roundup crop biomass has been found to release glyphosate into the air. Ironically we stop using leaded gasoline only to switch to glyphosate contaminated fuel. (glyphosate & Covid posts)

ACE2 receptors are found throughout the body with more in some types of tissue or organs. (22) The organ locations with more ACE2 receptors would be at more risk for tissue damage from a COVID19 infection.

Organ, tissue, and cell types where more ACE2 receptors tend to be located. (22)

Thread by @Parsifaler, Walter M Chestnut (11)

MALE INFERTILITY AND THE SPIKE PROTEIN

Mitochondria are damaged by the spike protein of SARS-CoV-2. Male infertility is caused by mitochondrial damage. Interestingly, since mtDNA is not in the nucleus, it is not considered to be germinal.

It is very likely that the protein of SARS-CoV-2 is causing male infertility in an unknown number of individuals. This is of utmost urgency as children are now being injected with spike protein therapeutics. These must be immediately stopped until studies can be done to determine the effect of the spike protein on male infertility.

They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.

“Thus, our in vivo study using mito-mice directly demonstrates that normal mitochondrial respiration is required for mammalian spermatogenesis, and its defects resulting from accumulated mutant mtDNAs cause male infertility.” (12)

Please read the referenced papers. (12, 13) – Walter M Chestnut @Parsifaler, (11)

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. ON Point with Alex Pierson,  New peer reviewed study on COVID-19 vaccines suggests why heart inflammation, blood clots and other dangerous side effects occur. omny.fm, https://omny.fm/shows/on-point-with-alex-pierson/new-peer-reviewed-study-on-covid-19-vaccines-sugge/embed?source=twitter&size=square&style=cover
  2. Depew J, Pomegranate peel catechins – inhibition of NET formation. May 14, 2020, https://transcendingsquare.com/2020/05/14/pomegranate-peel-catechins-inhibition-of-net-formation/
  3. Depew J, G13. Pomegranate. https://effectivecare.info/g13-pomegranate
  4. Vaccine Shedding and Transfer – Dr. Lee Merritt Explains the COVID Bioweapon. May 28, 2021, The New American, https://www.bitchute.com/video/Qqslv0tJCuPy/
  5. Technologies to Address Global Catastrophic Biological Risks (GCBR Tech Report), John Hopkins Bloomberg School for Public Health, Center for Health Security, https://www.dropbox.com/s/2w2ylb1fgfcck5h/181009-gcbr-tech-report.pdf?dl=0
  6. Mini-lecture Herd Immunity, collateralglobal.org, https://collateralglobal.org/article/mini-lecture-herd-immunity/
  7. Alana F Ogata, Chi-An Cheng, Michaël Desjardins, Yasmeen Senussi, Amy C Sherman, Megan Powell, Lewis Novack, Salena Von, Xiaofang Li, Lindsey R Baden, David R Walt, Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients, Clinical Infectious Diseases, 2021;, ciab465, https://doi.org/10.1093/cid/ciab465 https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075
  8. Image of a comment by E. Math about the article in (7) https://twitter.com/HomoSapiensUSA1/status/1398404844742975489?s=20
  9. Jack Chun-Chieh Hsu, Maudry Laurent-Rolle, Joanna B. Pawlak, Craig B. Wilen, Peter Cresswell, Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein. Proceedings of the National Academy of Sciences Jun 2021, 118 (24) e2101161118; DOI: 10.1073/pnas.2101161118 https://www.pnas.org/content/118/24/e2101161118
  10. Josh Boswell, EXCLUSIVE: COVID-19 ‘has NO credible natural ancestor’ and WAS created by Chinese scientists who then tried to cover their tracks with ‘retro-engineering’ to make it seem like it naturally arose from bats, explosive new study claims. May 28, 2021, dailymail.co.uk, https://www.dailymail.co.uk/news/article-9629563/Chinese-scientists-created-COVID-19-lab-tried-cover-tracks-new-study-claims.html
  11. Walter M Chestnut, Twitter Thread, @Parsifaler https://twitter.com/Parsifaler/status/1398440015399686147?s=20
  12. Kazuto Nakada, Akitsugu Sato, Kayo Yoshida, Takashi Morita, Hiromitsu Tanaka, Shin-Ichi Inoue, Hiromichi Yonekawa, Jun-Ichi Hayashi Mitochondria-related male infertility. Proceedings of the National Academy of Sciences Oct 2006, 103 (41) 15148-15153; DOI: 10.1073/pnas.0604641103 https://www.pnas.org/content/103/41/15148
  13. Emily Henderson, SARS-CoV-2’s distinctive “spike” protein plays a key role in the disease itself, shows study. May 3, 2021, news-medical.net, https://www.news-medical.net/news/20210503/SARS-CoV-2e28099s-distinctive-spike-protein-plays-a-key-role-in-the-disease-itself-shows-study.aspx#
  14. Eric Kowarz, Lea Krutzke, Jenny Reis et al., “Vaccine-Induced Covid-19 Mimicry” Syndrome: Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines. Preprint, DOI: 10.21203/rs.3.rs-558954/v1 https://www.researchsquare.com/article/rs-558954/v1
  15. Kim DH, Meza CA, Clarke H, Kim JS, Hickner RC. Vitamin D and Endothelial Function. Nutrients. 2020;12(2):575. Published 2020 Feb 22. doi:10.3390/nu12020575 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071424/
  16. Rani, Anita & Naaz, Huda & Rajni, Dawar & Kaur, Charanjeet. (2020). Emerging Role of Nutraceuticals in Covid 19 IAR Journal of Medicine and Surgery Research . 1. 74-82. https://www.researchgate.net/publication/348591712_IAR_Journal_of_Medicine_and_Surgery_Research_Emerging_Role_of_Nutraceuticals_in_Covid_19
  17. Johnson PL, Kochin BF, McAfee MS, et al. Vaccination alters the balance between protective immunity, exhaustion, escape, and death in chronic infections. J Virol. 2011;85(11):5565-5570. doi:10.1128/JVI.00166-11 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094965/
  18. COVID-19 vaccine AstraZeneca analysis print Report Run Date: 20-May-2021 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/989997/COVID-19_vaccine_AstraZeneca_analysis_print.pdf
  19. COVID-19 mRNA Pfizer- BioNTech vaccine analysis print Report Run Date: 20-May-2021, https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/989996/COVID-19_mRNA_Pfizer-_BioNTech_Vaccine_Analysis_Print.pdf
  20. COVID-19 vaccine Moderna analysis print Report Run Date: 20-May-2021, https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/989998/COVID-19_vaccine_Moderna_analysis_print.pdf
  21. COVID-19 vaccine brand unspecified analysis print Report Run Date: 20-May-2021, https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/990000/COVID-19_vaccine_brand_unspecified_analysis_print.pdf
  22. Chris Baraniuk, Receptors for SARS-CoV-2 Present in Wide Variety of Human Cells. April 29, 2020, the-scientist.com, https://www.the-scientist.com/news-opinion/receptors-for-sars-cov-2-present-in-wide-variety-of-human-cells-67496
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Transparency – of currency change & possibly control – theories of a financial industry author.

Catherine Austin Fitts Full Interview, interview by Ray Traylor on Vimeo.

Catherine Austin Fitts has financial industry experience and presents a case for financial changes to be part of the goal of the pandemic response in some developed nations. Digital IDs could be tied to bank accounts and be used as a form of social control of citizens. This seems far-fetched except many far-fetched things have been happening instead of a normal public health response to an epidemic.

Inducing fear may be to reduce resistance to the Lockdown rules and destruction of small businesses and wage worker’s income.

We are being manipulated by government and media messaging techniques and the inciting of fear. Early treatments are available and helping around the world – there is no reason they couldn’t help in the US and other developed nations too.

Methods of opinion manipulation tactics are listed in this Twitter Thread:

  • Fractionation: You get them to do something not once, but again and again, increasing the level of intensity each time. Usually you do this 3 times (note: we’ve have 3 lockdowns). This increases compliance – you’re much more likely to get them to do whatever you want (2)
  • A ‘Yes’ set: Get them to say ‘Yes’ to something small at first (2 weeks to “flatten the curve”) then gradually increase (months of lockdown, Christmas cancelled, socially/economically coerced into vaccines). In this way they’re much more likely to keep saying yes (3)
  • Confusion: Keep them in a constant state of uncertainty. The conscious mind responds by ‘going offline’ as it searches for the appropriate response for something it has no precedent for. Then it’s much easier for the manipulator to gain access to the unconscious mind… (4)
  • … and change belief systems. For example, lockdown rules are changing on practically a day-to-day basis; we’re living in a world we’ve never lived in before, everyone’s stumbling about with no idea how to behave. We’ve no energy left to fight our oppressors (5)
  • Repetition: Repeat the same information over and over (see any newspaper / TV news for evidence of this!) (6)
  • Illusion of Choice: Make them believe they’re in control by giving them 2 choices, both of which lead to the same result. For example, ‘Do you want the Pfeizer or the Oxford?’ or ‘You can choose to be good or bad. Bad = more lockdown. Good = more lockdown.’ (7)
  • “Social Proof“: Images and videos of film and TV stars, musicians and sportsmen and women receiving their jab. “Look, all these great celebrities are backing it!” (8)
  • “Scarcity“: “You’ll have to wait your turn for the vaccine… we might be running out!”, to create a surge in people booking in for their jab, thus increasing uptake (9). – (@miss_anthrop75)
  • Neuro-Linguistic Programming: Milton Model – (pciinstitute.net/nlp/milton-model/)

Using advertising strategies to manipulate a consumer’s behavior is wrong when used for promoting an experimental product that has unknown long-term risks. “First do no harm” and “Informed Consent” need to be an individual’s choice, not a government’s or a place of employment.

The spike protein itself may be the harm, leading to changes in the body that mimic early aging: “premature immunosenescence.” Detected in Covid19 survivors rather than people who got the mRNA gene treatments, however there are scientists concerned about similarities in adverse reactions to the treatments and COVID19 symptoms.

Infection may be increasing need for zinc which might be okay or low to begin with, especially in older adults, but more zinc is needed by the infection process for any age person. Children younger than ~ten usually have the best T-cell immunity, which requires zince and thymus gland function. As we get older the thymus gland function is reduced but suplementing with extra zinc has helped restore some thymus gland function in aging, in an animal based study. (1)

“Zinc and immunosenescence” (1)

  • Ageing is a continuous multidimensional process of physical, psychological and social changes that compromises the normal functioning of various organs and systems, including several immunological alterations named immunosenescence, which is characterised by increased susceptibility to infections, autoimmune diseases and cancer (Pawelec et al. 2010).
  • The immune efficiency decreases with advancing aging, starting around 60–65 years.
  • Alterations of the immune system during ageing and zinc deprivation show many similarities, indicating the existence of a strict relationship between immunosenescence and zinc deficiency (Mocchegiani et al. 1998; Bogden 2004). The similarity is in adaptive and innate immunity as well as in neutrophil functions (chemotaxis, phagocytosis, oxidative burst).
  • Although the total number of neutrophils is not different between old and young-adult subjects, phagocytosis, oxidative burst, and intracellular killing are impaired in ageing and neutrophils from the elderly show reduced chemotaxis and a lower resistance to apoptosis, as shown by impaired anti-apoptotic effects after specific stimuli (lipopolysaccharide (LPS), G-CSF and GM-CSF) (Schroder and Rink 2003).
  • In this context, zinc may play a key role because a satisfactory intracellular zinc ion bioavailability preserves the oxidative burst by neutrophils, via reduction of IL-6 signalling, as observed in centenarians, who in turn display satisfactory intracellular zinc content and low grade of inflammation (Moroni et al. 2005).“
  • 1. Mocchegiani E, Romeo J, Malavolta M, et al. Zinc: dietary intake and impact of supplementation on immune function in elderly. Age (Dordr). 2013;35(3):839-860. doi:10.1007/s11357-011-9377-3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636409/

Disclaimer: this information is shared for educational purposes within the guidelines of Fair Use.

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Niacin may help prevent or treat migraines.

Niacin may help prevent migraines or tension-type headaches when taken daily based on a review of nine articles about niacin use and migraines or tension-type headaches. It may also help end a migraine that is occurring with the cooling effect that follows the skin-reddening niacin flush.

  • The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature. (1)

“Chronic tension-type headaches are also associated with cerebrospinal pressure or intracranial venous pressure (or both) [26]. In fact, tension-type headaches are more similar to migraine headaches than they are dissimilar, in that they seem to progress into migraine headaches due to an escalating pathophysiological process [27].” (1)

Niacin may also help reduce a migraine that is occurring, with a 500 mg dose taken to cause the niacin flush.

Regarding one of the articles reviewed: “In this [self] report, Hall describes the use of niacin for his migraine headaches remarking that the migraines resolved when intense flushing occurred.” (1)

The vasodilation in the skin that causes the warm feeling and reddening of the skin is followed by a vasoconstriction and cooling effect on the body and brain. Older research confirmed vasoconstriction in the brain occurs as well as in the peripheral blood vessels, however current research is needed. (1)

From the Discussion section (1) : “When taken intravenously or orally, niacin causes cutaneous flushing that might abort the acute symptoms of migraine by vasodilating the intracranial vessels, thus preventing the subsequent vasoconstriction of the extracranial vessels.

There is evidence that niacin is an effective peripheral vasodilator, but its ability to influence central mechanisms (i.e., cerebral blood flow and cranial hemodynamics) involved in migraine headaches have not been well studied. Niacin causes peripheral vasodilation and cutaneous flushing by inducing the production of prostaglandin D2 (PGD2) in the skin, leading to a marked increase of its metabolite, 9α, 11β-PGF2, in the plasma [22].

When niacin is administered orally in amounts of 500 mg or topically via a 6-inch patch of 10-1 M aqueous methylnicotinate on the forearm, PGD2 is markedly released in the skin and its metabolite appears in high amounts in the plasma [22, 23]. It is not known if PGD2 causes vasodilation of the intracranial arteries, but niacin’s ability to abort acute migraine headaches suggests that this might be what is occurring.

Old reports cited by Bicknell and Prescott [24], demonstrate that niacin does indeed cause vasodilation of the cerebral and spinal vessels, and that intravenous administration increases the rate of intracranial blood flow in human beings for 20–60 minutes without any significant change in blood pressure. Unfortunately, there have not been more recent reports examining the effects that niacin has upon cerebral blood flow in human subjects.” (1)

Niacin (B3) is needed for Mitochondrial function…

…so are riboflavin (B2), other B vitamins; many trace minerals including magnesium; amino acid derived creatine and cysteine; and the internally made antioxidants CoQ10, glutathione and alpha-lipoic acid.

Niacin helps mitochondria function to burn glucose for energy use or to release as heat (such as in brown fat). Riboflavin and coenzyme Q10 and other nutrients are also used by the mitochondria. (1)

“A deficit of mitochondrial energy metabolism may play a role in the pathogenesis of migraine. Since niacin improves mitochondrial energy metabolism by increasing substrate availability to complex I, it might also be an effective agent for migraine prevention.” (1)

Citric Acid Cycle – used for aerobic glycolysis of glucose by the many many Mitochondria within all of our cells.

Graphic (via Dmitry Kats, PhD, @NiacinisHealth) shows the many nutrients that are used in the Citric Acid Cycle by mitochondria when they are metabolizing glucose aerobically, with oxygen, as typical of their normal function. Anaerobic glycolysis, fermentation of glucose or glutamate without oxygen, by mitochondria is associated with cancerous cells.
Nutrients include: B1 (thiamin), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), Mg++ (magnesium), Mn++ (manganese), K+ (potassium), zinc, iron, copper, sulfate, CoQ10, carnitine, cysteine, glutathione, Lipoic acid.

B vitamins are very important and we need them in balance because they work as a team. Niacin might not help as much if there is significant lack of the other B vitamins or some of the minerals, amino acids or antioxidants needed for the Citric Acid Cycle to function. The nutrients mentioned as cofactors for the chemical reactions in the above graphic include:

  • B vitamins: B1 (thiamin) (3) , B2 (riboflavin) (4), B3 (niacin) (8, 10), B5 (pantothenic acid) (5), B6 (pyridoxine) (6, 7), B7 (biotin), B9 (folate) (9),
  • Minerals (17): Mg++ (magnesium) (11, 12, 13), Mn++ (manganese), K+ (potassium) (13), zinc (14, 15), iron (16), copper, sulfate,
  • Amino acids: carnitine (derived from lysine), cysteine,
  • Antioxidants: CoQ10, glutathione, alpha-Lipoic acid (ALA).

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Prousky, J., Seely, D. The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature. Nutr J4, 3 (2005). https://doi.org/10.1186/1475-2891-4-3 https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-4-3
  2. Dmitry Kats, PhD, @NiacinisHealth Citric Acid Cycle graphic
  3. Thiamin: people with anorexia or alcoholism are more at risk for vitamin B1 deficiency. Aug 21, 2013 https://transcendingsquare.com/2013/08/21/thiamin/
  4. Riboflavin – Vitamin B2, May 23, 2018, https://transcendingsquare.com/2018/05/23/riboflavin-vitamin-b2/
  5. Pantothenic Acid – vitamin B5, May 24, 2018 https://transcendingsquare.com/2018/05/24/pantothenic-acid-vitamin-b5/
  6. Vitamin B6, https://transcendingsquare.com/2013/08/21/vitamin-b6-2/
  7. Pyroluria, anxiety and deficiency of B6 and zinc, most recent update, 4/9/2017 https://transcendingsquare.com/2014/09/22/pyroluria-anxiety-and-deficiency-of-b6-and-zinc/
  8. Niacin, & early treatment in general for SARS-CoV-2 is sensible, reduces hospitalization and mortality rate. https://transcendingsquare.com/2021/01/22/niacin-early-treatment-in-general-for-sars-cov-2-is-sensible-reduces-hospitalization-and-mortality-rate/
  9. Folate is essential and Folic Acid is commonly available. Aug 21, 2013, https://transcendingsquare.com/2013/08/21/folate-and-folic-acid-2/
  10. Niacin, Aug 21, 2013, https://transcendingsquare.com/2013/08/21/niacin/
  11. To have optimal Magnesium needs Protein and Phospholipids too. July 20, 2018, https://transcendingsquare.com/2018/07/20/to-have-optimal-magnesium-needs-protein-and-phospholipids-too/
  12. Magnesium – essential for eighty percent of our body’s chemistry. July 1, 2019, https://transcendingsquare.com/2019/07/01/magnesium-essential-for-eighty-percent-of-our-bodys-chemistry/
  13. Electrolytes are essential, magnesium helps protect brain cells. Feb 10, 2011, https://transcendingsquare.com/2011/02/10/electrolytes-r-us-magnesium-saves-brain-cells/
  14. Zinc, https://jenniferdepew.com/zinc
  15. Zinc and the immune system, https://www.peace-is-happy.org/post/zinc-and-the-immune-system
  16. Iron and anemia of chronic inflammation. https://www.peace-is-happy.org/post/iron-and-anemia-of-chronic-inflammation
  17. Trace Minerals – It’s Teamwork. https://www.peace-is-happy.org/post/trace-minerals-it-s-teamwork
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Glycine – good for our extracellular matrix & for immune protection against viral infection.

The extracellular matrix is very important for our immune defense as white blood cells actively patrol the areas surrounding cells for pathogens to remove, such as virus. Deficiency of glycine may be involved for patients with more severe COVID-19. “Glycine intake as nutritional supplement was very effective against virus infections.” (1)

Glycine is an amino acid and is important in the structure of protein chains because it is small in size and can allow folding of the long chain into a three dimensional shape. (See post: Glyphosate & COVID19) It is important within proteins (such as collagen) that help stabilize the gooey gelatin like fluid that supports the areas within our cells and surrounding our cells. There can be a thicker layer immediately surrounding cells which is called a glycocalyx, a term also used to describe the gel coating that surrounds bacteria.

“Biofilms formed by an alginate-overproducing strain of Pseudomonas aeruginosa have a complex structural architecture that allows them to more resist tobramycin than biofilms formed by an isogenic nonmucoid strain. This suggests that an altered structure of biofilms cause increased resistance of pathogens against antibiotics.182 ” (9)

It helps protect our cells from bacteria, virus and other pathogens. A stronger extracellular matrix, made possible with daily supplements of 10 grams of glycine, was found to help protect against viral infection. (1)

Glycine is used often in the assembly of collagen proteins. The small glycine molecules help stabilize the triple helix shape of the long column like folded protein. The long sturdy fiber like proteins help add stability and structure to the three dimensional woven mesh of the fluid gelatin like extracellular matrix or cytoplasm within cells.

“Glycine is utilized to synthesize serine, sarcosine, purines, creatine, heme group, glutathione, and collagen. Glycine is a major quantitative component of collagen. In addition, the role of glycine maintaining collagen structure is critical, as glycine residues are required to stabilize the triple helix of the collagen molecule.“

The collagen fibers can be chemically stained for viewing on microscope slides. In an image here (7, 8) the collagen fibers are greenish and surround the cells that each have a brownish-black nucleus in the middle.

Extracellular matrix – our glycocalyx – our jelly lining.

We need a healthy extracellular matrix that is not too sticky and dehydrated to prevent easy flow of fluid and cells and not too watery as some solid support is needed. We are almost 70% water but it doesn’t seem like it. Magnesium is also essential for the structure of the gelatin like matrix within and surrounding cells. Each atom of magnesium can hold 18 molecules of water in an electrically stabilized cloud of water surrounding the magnesium atom. Sulfates are also essential for the stability of the matrix structure. Monosaccharides, single molecules of sugars, are also an important part of the glycocalyx on cell surfaces. Different types of monosaccarides are combined into surface glycoproteins that tell the immune system information about the cell – whether friend or foe.

Many of the extracellular proteins, such as sialic acid, also carry a negative electrical charge so there is a slight magnetic like repelling against other cells. This is critically important for holding vessel walls open – the negative charge surrounding the interior repels the other wall from collapsing inward. Some food additive emulsifiers may be too effective and also may emulsify our intestinal lining and cause bowel troubles such as diarrhea and discomfort. Gumbo file is a very healthy emulsifier from nature -powdered sassafras leaves – used by indigenous Americans.

“Cells encounter surrounding surfaces first through their glycocalyx and therefore it may substantially contribute to crucial physiological and pathophysiological processes. The glycocalyx is a carbohydrate-enriched sugar coating that covers the surface of many cells, including cancer cells, presumably greatly influencing cellular interactions with their environment at the molecular scale. Its components are glycolipids, glycoproteins and glycosaminoglycans (GAGs). Glycocalyx contains large amounts of chondroitin sulfate (CS), dermatan sulfate, heparan sulfate, sialic acid, and hyaluronic acid, all negatively charged at neutral pH21.” (4)

The amino acid Glycine – available in supplements as Dimethylglycine (DMG) and Trimethylglycine (TMG).

Glycine is available as a bulk powder available from protein supplement companies focused on the weight lifting industry. Betaine is the more common name for Trimethylglycine (TMG), it and Dimethylglycine (DMG) are available as supplements in tablets or powders. It may be helpful to have both as they are used for different purposes and are not exactly equivalent. DMG can cross the blood brain barrier so it is helpful when the calming inhibitory effects of glycine are needed within the brain. (2)

“Dimethylglycine (DMG) is an amino acid found naturally in plant and animal cells and in many foods such as beans, cereal grains, and liver. It is used to improve energy, boost the immune system, and to manage seizures and autism. There are some positive reports of DMG efficacy on the immune system.” (3)

DMG may be helpful for people with seizure risk – it was found to help some patients but not showing conclusively positive results overall. Some patients may have a genetic difference and need an external supply. (3)

People with a BHMT gene allele (like myself) would need an external source of DMG as the BHMT enzyme is needed to breakdown betaine to DMG. You can see the chemical steps in a graphic here: (6). From a previous post: “DMG has been found helpful in ADHD, autism, allergies, alcoholism, drug addiction, and chronic fatigue syndrome among other chronic issues.” See #3. BHMT in this post: Methylation Cycle Defects – in me – genetic screening “for research purposes only” A more recent post goes into further detail about the BHMT enzyme’s role in the production and breakdown of endocannabinoids. Cannabinoids are made with the BHMT gene (and others).

I have a double BHMT gene allele – I need an external source of DMG and methionine and it helped my mood immensely. It helps me feel more cheerful as well as more energetic. I take about a half teaspoon of each once or twice a day. A teaspoon at a time was too much energetic, seemed to cause a racing heart rate. The total amount a person needs per day may be more than that. Capsules would be giving a smaller amount, I didn’t notice much effect at all from taking a little tablet supplement and the price was significantly larger. A half teaspoon of a powder is about 2.5 grams, a tablet is usually about 500 milligrams, 0.5 grams.

I am not taking enough DMG and I hadn’t realized TMG might be helpful too – what I also hadn’t realized is TMG is betaine – so I should be taking the DMG form, I get betaine from food and I don’t do well with too much of a good source (quinoa). We need about 10 grams of glycine per day from dietary sources, yet the typical diet only provides two grams. “Glycine produced by human metabolism is much lower than the cell’s needs giving a general glycine deficiency of 10 g/day in humans.” (1)

People who took ten grams of glycine per day as a supplement had fewer viral infections than the control group. (1) “Glycine intake at the afore-mentioned dose prevents the spread of viruses by strengthening the extracellular matrix barriers against their advance. ” (1)

Nutritional supplement, 10 g/day, Glycine, promotes young strong collagen, compared to old weak collagen formed from an un-supplemented diet (~2 gr/day) and our own metabolic pathways (~3 gr/day). Graphic from: “Glycine can prevent and fight virus invasiveness by reinforcing the extracellular matrix” (Meléndez-Hevia, et al., 2021) (1)

Gee, I do want “young, strong collagen” (see above image, (1)) , so I will have my glycine drink four times a day. Breaktime, be right back. I will be so cheerful it may be hard to recognize me. 🙂

  • My “Cheerful Juice” drink reminds me of red wine without the alcohol, ~ 10 oz water, 1/2 teaspoon DMG, 1/2 tsp methionine; a little of my coffee sweetener mix: Stevia, powdered cardamom, sage and oregano; 2 ounces pomegranate juice. If I had taurine and creatine on hand I would try adding that too, but amino acids are acidic. The beverage is tart and I sip it slowly.

People with a genetic problem with methylation may have problems making a variety of proteins, as well as people with a diet deficient in the methyl donating nutrients folate, B12, betaine, choline, and the amino acid methionine. “Studies that simulated methyl-deficient diets reported disturbances in energy metabolism and protein synthesis in the liver, fatty liver, or muscle disorders.” […] “Hypomethylation has a wide spectrum of effects that include genetic, epigenetic, and metabolic alterations.” (5) Someone with a genetic problem with methylation would need to take the bioactive, methylated form of B12 and folate. The standard supplement of folic acid and cyanocobalamin are unmethylated forms and would be not helpful for someone unable to remethylate them.

Summary – to fight virus well, we need a healthy extracellular matrix for white blood cells to be able to patrol easily — and to have that we need adequate glycine in our diet and the genetic ability to digest it to Dimethylglycine (DMG).

  • We also need to stay well hydrated, and to have adequate sulfate, magnesium, protein and ATP for magnesium storage, and a wide variety of monosaccharides to make surface glycoproteins that say and do the correct functions as cell surface immune markers.
  • Epsom salt soaks may be helpful as a topical source of magnesium and sulfate for people with poor intestinal absorption of magnesium, or sometimes there can be a genetic difference limiting intestinal absorption for the person’s whole life.
  • Fiber rich plant foods are also needed to support the extracellular matrix – similar to how gelatin is supported by fruit pectin fibers when making jams.
  • We can’t do much without B vitamins – they are the body’s energy providers, essential for our mitochondria. Lack can lead to mitochondria switching to anaerobic glycolysis which may be a risk for later transition to cancer. Methylated forms of folate and B12 are needed by people with certain gene differences. Niacin in a much higher dose than would be available from the diet can help reduce inflammation, (niacin post) and also help preserve tryptophan stores for use to make serotonin and melatonin (see last post).

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Enrique Meléndez-Hevia, Patricia de Paz-Lugo, Guillermo Sánchez, Glycine can prevent and fight virus invasiveness by reinforcing the extracellular matrix. J Functional Foods, Vol 76, 2021, 104318, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2020.104318. https://www.sciencedirect.com/science/article/pii/S1756464620305429
  2. Is TMG or DMG more effective?, davincilabs.com, https://blog.davincilabs.com/blog/is-tmg-or-dmg-more-effective
  3. Dimethylglycine: Purported Uses, mskcc.org https://www.mskcc.org/cancer-care/integrative-medicine/herbs/dimethylglycine
  4. Kanyo, N., Kovacs, K.D., Saftics, A. et al. Glycocalyx regulates the strength and kinetics of cancer cell adhesion revealed by biophysical models based on high resolution label-free optical data. Sci Rep10, 22422 (2020). https://doi.org/10.1038/s41598-020-80033-6 https://www.nature.com/articles/s41598-020-80033-6
  5. Obeid R. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients. 2013;5(9):3481-3495. Published 2013 Sep 9. doi:10.3390/nu5093481 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798916/
  6. Glycine formation from betaine-trimethylglycine. image https://www.researchgate.net/figure/Glycine-formation-from-betaine-trimethylglycine-BHMT-betaine-homocysteine_fig5_320773132 from Adeva, María & Souto-Adeva, G. & Ameneiros-Rodríguez, E. & Fernández-Fernández, C. & Donapetry-García, C. & Domínguez-Montero, A.. (2018). Insulin resistance and glycine metabolism in humans. Amino Acids. 50. 10.1007/s00726-017-2508-0. https://www.researchgate.net/publication/320773132_Insulin_resistance_and_glycine_metabolism_in_humans
  7. Collagen Fiber, sciencedirect.com, https://www.sciencedirect.com/topics/medicine-and-dentistry/collagen-fiber see,
  8. Michal Miko, Ivan Varga, Chapter 6 – Histologic Examination of Peripheral Nerves, Editor(s): RS Tubbs, E Rizk, MM. Shoja, M Loukas, N Barbaro, RJ Spinner, Nerves and Nerve Injuries, Academic Press, 2015, Pages 79-89, ISBN 9780124103900, https://doi.org/10.1016/B978-0-12-410390-0.00006-8. https://www.sciencedirect.com/science/article/pii/B9780124103900000068
  9. Baral B, Mozafari MR. Strategic Moves of “Superbugs” Against Available Chemical Scaffolds: Signaling, Regulation, and Challenges. ACS Pharmacol Transl Sci. 2020;3(3):373-400. Published 2020 Apr 13. doi:10.1021/acsptsci.0c00005 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296549/